Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

• Published in: Molecular neurodegeneration Vol. 12; no. 1; pp. 43 - 12
• Main Authors: Efthymiou, Anastasia G., Goate, Alison M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.05.2017; BMC
• Subjects: Age of Onset; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer's disease; Amyloid; Animals; Biomarkers; Disease; Drug development; Gene expression; Gene Regulatory Networks - genetics; Gene Regulatory Networks - immunology; Genetic Predisposition to Disease - genetics; Genetics; Genomes; Genomics; Humans; Hypotheses; Immunosuppressive agents; Lipids; Microglia; Microglia - immunology; Microglia - pathology; Mutation; Myeloid; Neurodegeneration; Neurodegenerative diseases; Pathology; Plaques; Review; Risk Factors; Rodents; Studies; Genetics; Myeloid; Alzheimer’s disease; Microglia

Alzheimer's disease (AD) is a highly heritable complex disease with no current effective prevention or treatment. The majority of drugs developed for AD focus on the amyloid cascade hypothesis, which implicates Aß plaques as a causal factor in the disease. However, it is possible that other und...