Potential Tear Biomarkers for the Diagnosis of Parkinson's Disease-A Pilot Study

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, = 24), carriers of the E46K-SNCA mutation ( = 3) and healthy control (CT, = 27) subjects was analyzed to ide...

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Published inProteomes Vol. 10; no. 1; p. 4
Main Authors Acera, Arantxa, Gómez-Esteban, Juan Carlos, Murueta-Goyena, Ane, Galdos, Marta, Azkargorta, Mikel, Elortza, Felix, Ruzafa, Noelia, Ibarrondo, Oliver, Pereiro, Xandra, Vecino, Elena
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.01.2022
MDPI
Subjects
Alzheimer's disease
Apoptosis
Biomarkers
Collagen
Dementia
Diagnosis
Immune response
Liquid chromatography
lysosome
Mass spectroscopy
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
Neurological complications
Parkinson's disease
Peptides
Phenotypes
Protein biosynthesis
Protein transport
Proteins
Proteomes
Proteomics
Scientific imaging
Software
tear film
St Louis Missouri
United Kingdom > UK
United States > US
Germany
Spain
tear film
lysosome
biomarkers
Parkinson’s disease
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Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, = 24), carriers of the E46K-SNCA mutation ( = 3) and healthy control (CT, = 27) subjects was analyzed to identify candidate biomarkers for the diagnosis of PD. An observational, prospective and case-control pilot study was carried out, analyzing the participants tear samples by nano-liquid chromatography-mass spectrometry (nLC-MS/MS) and assessing their neurological impairment. The proteomic data obtained are available at ProteomeXchange with identifier 10.6019/PXD028811. These analyses led to the identification of 560 tear proteins, some of which were deregulated in PD patients and that have been implicated in immune responses, inflammation, apoptosis, collagen degradation, protein synthesis, defense, lipid transport and altered lysosomal function. Of these proteins, six were related to neurodegenerative processes and showed a good capacity to classify patients and controls. These findings revealed that certain proteins were upregulated in the tears of PD patients, mainly proteins involved in lysosomal function. Thus, in this study, tear proteins were identified that are implicated in neurodegeneration and that may be related to an aggressive disease phenotype in PD patients.
AbstractList Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA mutation (n = 3) and healthy control (CT, n = 27) subjects was analyzed to identify candidate biomarkers for the diagnosis of PD. An observational, prospective and case-control pilot study was carried out, analyzing the participants tear samples by nano-liquid chromatography–mass spectrometry (nLC–MS/MS) and assessing their neurological impairment. The proteomic data obtained are available at ProteomeXchange with identifier 10.6019/PXD028811. These analyses led to the identification of 560 tear proteins, some of which were deregulated in PD patients and that have been implicated in immune responses, inflammation, apoptosis, collagen degradation, protein synthesis, defense, lipid transport and altered lysosomal function. Of these proteins, six were related to neurodegenerative processes and showed a good capacity to classify patients and controls. These findings revealed that certain proteins were upregulated in the tears of PD patients, mainly proteins involved in lysosomal function. Thus, in this study, tear proteins were identified that are implicated in neurodegeneration and that may be related to an aggressive disease phenotype in PD patients.
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, = 24), carriers of the E46K-SNCA mutation ( = 3) and healthy control (CT, = 27) subjects was analyzed to identify candidate biomarkers for the diagnosis of PD. An observational, prospective and case-control pilot study was carried out, analyzing the participants tear samples by nano-liquid chromatography-mass spectrometry (nLC-MS/MS) and assessing their neurological impairment. The proteomic data obtained are available at ProteomeXchange with identifier 10.6019/PXD028811. These analyses led to the identification of 560 tear proteins, some of which were deregulated in PD patients and that have been implicated in immune responses, inflammation, apoptosis, collagen degradation, protein synthesis, defense, lipid transport and altered lysosomal function. Of these proteins, six were related to neurodegenerative processes and showed a good capacity to classify patients and controls. These findings revealed that certain proteins were upregulated in the tears of PD patients, mainly proteins involved in lysosomal function. Thus, in this study, tear proteins were identified that are implicated in neurodegeneration and that may be related to an aggressive disease phenotype in PD patients.
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients with idiopathic PD (iPD, n = 24), carriers of the E46K-SNCA mutation ( n = 3) and healthy control (CT, n = 27) subjects was analyzed to identify candidate biomarkers for the diagnosis of PD. An observational, prospective and case-control pilot study was carried out, analyzing the participants tear samples by nano-liquid chromatography–mass spectrometry (nLC–MS/MS) and assessing their neurological impairment. The proteomic data obtained are available at ProteomeXchange with identifier 10.6019/PXD028811. These analyses led to the identification of 560 tear proteins, some of which were deregulated in PD patients and that have been implicated in immune responses, inflammation, apoptosis, collagen degradation, protein synthesis, defense, lipid transport and altered lysosomal function. Of these proteins, six were related to neurodegenerative processes and showed a good capacity to classify patients and controls. These findings revealed that certain proteins were upregulated in the tears of PD patients, mainly proteins involved in lysosomal function. Thus, in this study, tear proteins were identified that are implicated in neurodegeneration and that may be related to an aggressive disease phenotype in PD patients.
Author Ibarrondo, Oliver
Gómez-Esteban, Juan Carlos
Ruzafa, Noelia
Vecino, Elena
Acera, Arantxa
Murueta-Goyena, Ane
Azkargorta, Mikel
Galdos, Marta
Elortza, Felix
Pereiro, Xandra
AuthorAffiliation 3 Department of Neurology, Cruces University Hospital, 48903 Barakaldo, Spain; juancarlos.gomezesteban@gmail.com
7 Department of Proteomics, Center for Cooperative Research in Biosciences, 48160 Derio, Spain; mazkargorta@cicbiogune.es (M.A.); felortza@cicbiogune.es (F.E.)
4 Neurodegenerative Diseases Group, BioCruces Health Research Institute, 48903 Barakaldo, Spain; ane.muruetagoyena@gmail.com
8 RS-Statistics, 20500 Arrasate, Spain; oibarrondo@rs-statistics.com
6 Begiker-Ophthalmology Research Group, BioCruces Health Research Institute, 48903 Barakaldo, Spain; marta.gal2@gmail.com
1 Experimental Ophthalmo-Biology Group, Department of Cell Biology and Histology, University of the Basque Country UPV/EHU, 48940 Leioa, Spain; aacera71@gmail.com (A.A.); noelia.ruzafa@ehu.eus (N.R.); xandra.pereiro@gmail.com (X.P.)
2 Department of Neuroscience, Biodonostia Health Research Institute, 20014 Donostia-San Sebastian, Spain
5 Department of Neurosciences, Faculty of Medicine and Nursery, University of th
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Issue 1
Keywords tear film
lysosome
biomarkers
Parkinson’s disease
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Snippet Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. In this study, the tear proteome profile of patients...
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. In this study, the tear proteome profile of patients...
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StartPage 4
SubjectTerms Alzheimer's disease
Apoptosis
Biomarkers
Collagen
Dementia
Diagnosis
Immune response
Liquid chromatography
lysosome
Mass spectroscopy
Movement disorders
Mutation
Neurodegeneration
Neurodegenerative diseases
Neurological complications
Parkinson's disease
Peptides
Phenotypes
Protein biosynthesis
Protein transport
Proteins
Proteomes
Proteomics
Scientific imaging
Software
tear film
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Title Potential Tear Biomarkers for the Diagnosis of Parkinson's Disease-A Pilot Study
URI https://www.ncbi.nlm.nih.gov/pubmed/35076620
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https://pubmed.ncbi.nlm.nih.gov/PMC8788479
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Volume 10
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