Protease-Activated Receptor 2 Has Pivotal Roles in Cellular Mechanisms Involved in Experimental Periodontitis

• Published in: Infection and Immunity Vol. 78; no. 2; pp. 629 - 638
• Main Authors: Wong, David M, Tam, Vivian, Lam, Roselind, Walsh, Katrina A, Tatarczuch, Liliana, Pagel, Charles N, Reynolds, Eric C, O'Brien-Simpson, Neil M, Mackie, Eleanor J, Pike, Robert N
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2010; American Society for Microbiology (ASM)
• Subjects: Alveolar Bone Loss - immunology; Alveolar Bone Loss - pathology; Animals; Biological and medical sciences; Bone resorption; CD4 antigen; CD8 antigen; CD90 antigen; Cytokines - immunology; Flow Cytometry; Fundamental and applied biological sciences. Psychology; g-Interferon; Granulocyte-macrophage colony-stimulating factor; Helper cells; Host Response and Inflammation; Inflammation; Interleukin 2; Lymphocyte Activation - immunology; Lymphocytes T; Mast cells; Mast Cells - immunology; Mice; Mice, Knockout; Microbiology; Periodontitis; Periodontitis - immunology; Periodontitis - pathology; Porphyromonas gingivalis; Porphyromonas gingivalis - immunology; Receptor, PAR-2 - immunology; T-cell receptor; T-Lymphocyte Subsets - immunology; T-Lymphocytes - immunology; Thy-1 Antigens - biosynthesis; Thy-1 Antigens - immunology; Tumor necrosis factor-a; Peptidases; Periodontal disease; Periodontitis; Enzyme; Stomatology; Hydrolases; Immunity; Mechanism

The tissue destruction seen in chronic periodontitis is commonly accepted to involve extensive upregulation of the host inflammatory response. Protease-activated receptor 2 (PAR-2)-null mice infected with Porphyromonas gingivalis did not display periodontal bone resorption in contrast to wild-type-i...