A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 23; p. 4215
• Main Authors: Wan, Weiwei, Wang, Liangjie, Chen, Xi, Zhu, Shenglin, Shang, Weijuan, Xiao, Gengfu, Zhang, Lei-Ke
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.11.2019; MDPI
• Subjects: Bioinformatics; chchd2; Cytoplasm; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA Replication - physiology; DNA viruses; DNA, Viral - biosynthesis; DNA, Viral - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Fractionation; Gene expression; Glycoproteins; HEK293 Cells; Herpes simplex; herpes simplex virus type 1; Herpes viruses; Herpesvirus 1, Human - physiology; Humans; ifitm3; Infections; Interferon; Kinases; Latency; Mass spectrometry; Mass spectroscopy; Membrane Proteins - genetics; Membrane Proteins - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Peptides; Proteins; Proteomics; quantitative proteomics; Regulation; RNA polymerase; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Signal transduction; Stimulators; Toll-like receptors; Transcription Factors - genetics; Transcription Factors - metabolism; trim27; Viral infections; Virus Replication - physiology; Viruses; virus–host interaction; IFITM3; herpes simplex virus type 1; CHCHD2; virus–host interaction; Quantitative proteomics; TRIM27

Herpes simplex virus type 1 (HSV-1) is widespread double-stranded DNA (dsDNA) virus that establishes life-long latency and causes diverse severe symptoms. The mechanisms of HSV-1 infection and HSV-1's interactions with various host cells have been studied and reviewed extensively. Type I interf...