Novel Bispidine-Monoterpene Conjugates—Synthesis and Application as Ligands for the Catalytic Ethylation of Chalcones

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 24; p. 7539
• Main Authors: Suslov, Evgeniy V., Ponomarev, Konstantin Y., Patrusheva, Oxana S., Kuranov, Sergey O., Okhina, Alina A., Rogachev, Artem D., Munkuev, Aldar A., Ottenbacher, Roman V., Dalinger, Alexander I., Kalinin, Mikhail A., Vatsadze, Sergey Z., Volcho, Konstantin P., Salakhutdinov, Nariman F.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.12.2021; MDPI
• Subjects: Alcohol; bispidines; catalysis; chalcones; Chloride; dialkylzincs addition; Hydrochloric acid; Iodine; Ligands; monoterpenoids; natural compounds; Nitrogen; chalcones; natural compounds; dialkylzincs addition; catalysis; ethylation; monoterpenoids; chiral ligands; bispidines; nickel complexes

A number of new chiral bispidines containing monoterpenoid fragments have been obtained. The bispidines were studied as ligands for Ni-catalyzed addition of diethylzinc to chalcones. The conditions for chromatographic analysis by HPLC-UV were developed, in which the peaks of the enantiomers of all s...