New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2 - Salomatina, Oksana V.; Dyrkheeva, Nadezhda S.; Popadyuk, Irina I.; Zakharenko, Alexandra L.; Ilina, Ekaterina S.; Komarova, Nina I.; Reynisson, Jóhannes; Salakhutdinov, Nariman F.; Lavrik, Olga I.; Volcho, Konstantin P. (Molecules (Basel, Switzerland), 2021)
Keywords: Acids; amide; Apoptosis; Binding Sites; cancer; Cancer therapies; Cell Line; Chemical Phenomena; Chemistry Techniques, Synthetic; Chromatography; Cytotoxicity; deoxycholic acid; Deoxycholic Acid - analogs & derivatives; Deoxycholic Acid - chemistry; Deoxycholic Acid - pharmacology; DNA repair; Enzyme Activation - drug effects; Enzymes; Humans; Models, Molecular; Molecular Conformation; Molecular Structure; Organic chemicals; oxadiazoles; Peptides; Phosphodiesterase Inhibitors - chemical synthesis; Phosphodiesterase Inhibitors - chemistry; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - chemistry; Phosphoric Diester Hydrolases - metabolism; Protein Binding; Recombinant Proteins - chemistry; Steroids; Structure-Activity Relationship; TDP1 inhibitor; TDP2 inhibitor; TDP1 inhibitor; TDP2 inhibitor; amide; molecular modeling; tumor; oxadiazoles; cancer; deoxycholic acid