Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

• Published in: Particle and fibre toxicology Vol. 13; no. 1; p. 15
• Main Authors: Labib, Sarah, Williams, Andrew, Yauk, Carole L., Nikota, Jake K., Wallin, Håkan, Vogel, Ulla, Halappanavar, Sabina
• Format: Journal Article
• Language: English
• Published: England BioMed Central 15.03.2016
• Subjects: Animal models; Animals; Benchmarking; Bioassays; Bioinformatics; Carbon; Chemical properties; Chemicals; Computational Biology; Databases, Genetic; Dose-Response Relationship, Drug; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation - drug effects; Gene Regulatory Networks - drug effects; Genomes; Genomics; Health risks; Humans; Laboratories; Lesions; Lung - drug effects; Lung - metabolism; Lung - pathology; Lungs; Male; Mice; Nanomaterials; Nanotechnology; Nanotubes, Carbon - toxicity; Occupational safety; Oligonucleotide Array Sequence Analysis; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - genetics; Pulmonary Fibrosis - pathology; Risk Assessment; Time Factors; Toxicity; Toxicogenetics; Transcription, Genetic - drug effects; United States > US; Case study; Nano; Risk assessment; Toxicogenomics; Lung fibrosis; Adverse outcome pathways; Benchmark dose

A diverse class of engineered nanomaterials (ENMs) exhibiting a wide array of physical-chemical properties that are associated with toxicological effects in experimental animals is in commercial use. However, an integrated framework for human health risk assessment (HHRA) of ENMs has yet to be estab...