Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes - Labib, Sarah; Williams, Andrew; Yauk, Carole L.; Nikota, Jake K.; Wallin, Håkan; Vogel, Ulla; Halappanavar, Sabina (Particle and fibre toxicology, 2016)
Keywords: Animal models; Animals; Benchmarking; Bioassays; Bioinformatics; Carbon; Chemical properties; Chemicals; Computational Biology; Databases, Genetic; Dose-Response Relationship, Drug; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation - drug effects; Gene Regulatory Networks - drug effects; Genomes; Genomics; Health risks; Humans; Laboratories; Lesions; Lung - drug effects; Lung - metabolism; Lung - pathology; Lungs; Male; Mice; Nanomaterials; Nanotechnology; Nanotubes, Carbon - toxicity; Occupational safety; Oligonucleotide Array Sequence Analysis; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - genetics; Pulmonary Fibrosis - pathology; Risk Assessment; Time Factors; Toxicity; Toxicogenetics; Transcription, Genetic - drug effects; United States--US; Case study; Nano; Risk assessment; Toxicogenomics; Lung fibrosis; Adverse outcome pathways; Benchmark dose