Chantriolides F–P, Highly Oxidized Withanolides with Hepatoprotective Activity from Tacca chantrieri

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 23; p. 8197
• Main Authors: Yang, Yue, Zhou, Fei, Wang, Min, Turanazarov, Mukhammadrizo, Wang, Xiao-Rong, Ke, Changqiang, Yao, Sheng, Lin, Ligen, Tang, Chunping, Ye, Yang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.11.2022; MDPI
• Subjects: chantriolides F–P; Chlorine; Crystals; Dioscoreaceae - chemistry; Experiments; hepatoprotective effect; Oxidative Stress; Radiation; Reactive oxygen species; Reactive Oxygen Species - analysis; Rhizome - chemistry; structural elucidation; Tacca chantrieri; tert-Butylhydroperoxide - pharmacology; withanolides; Withanolides - pharmacology; structural elucidation; withanolides; Tacca chantrieri; hepatoprotective effect; chantriolides F–P

Eleven highly oxidized withanolides, chantriolides F–P (1–11), together with six known analogues (12–17), were isolated from the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis and comparison with published NMR data, and their...