Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 9; p. 1413
• Main Authors: Shi, Yu-Sheng, Zhang, Yan, Hu, Wen-Zhong, Zhang, Xiu-Fu, Fu, Xin, Lv, Xia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.08.2017; MDPI
• Subjects: Animals; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Arthritis; Cell Line, Tumor; Chalcones - chemistry; Chalcones - isolation & purification; Chalcones - pharmacology; Chromatography, High Pressure Liquid; Circular Dichroism; cytotoxic activity; Cytotoxicity; dihydrochalcone; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoid; Drug dosages; Edema; Ethanol; Flavonoids; Humans; inhibitory activity on nitric oxide production; Laboratories; Macrophage Activation - drug effects; Mice; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Pteris - chemistry; Pteris ensiformis; Short Note; Spectrum analysis; Pteris ensiformis; inhibitory activity on nitric oxide production; cytotoxic activity; diterpenoid; dihydrochalcone
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22091413

Two new dihydrochalcone enantiomers (+)-1 and (−)-1, along with eight known compounds 3–10, were obtained from Pteris ensiformis. The planar structures were determined on the basis of extensive 1D and 2DNMR and HRESIMS. The resolution of (+)-1 and (−)-1 was achieved by chiral HPLC analysis. The abso...