Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting
The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and epidemiological findings from routine surveillance. We identified...
Saved in:
Published in | Epidemiology and infection Vol. 138; no. 10; pp. 1459 - 1467 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Cambridge, UK
Cambridge University Press
01.10.2010
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and epidemiological findings from routine surveillance. We identified 819 cases, of whom 389 returned surveillance questionnaires. A subset of 267 faecal samples was submitted for typing by sequencing of the triose phosphate isomerase (tpi) and ribosomal RNA genes, and/or a separate duplex PCR of the tpi gene. Typing was successful in 199 (75%) samples by at least one of the molecular methods. Assemblage A accounted for 48 (24%) samples and Assemblage B for 145 (73%); six (3%) were mixed. Both assemblages had similar seasonality, age distribution and association with travel. Clinical features were available for 59 successfully typed cases: both assemblages caused similar illness, but Assemblage A was significantly more frequently associated with fever than Assemblage B. |
---|---|
Bibliography: | PII:S0950268810000208 istex:1B8A790458AE233F5E7A4117C0C819916DAA591D ark:/67375/6GQ-NWCV6Q46-K ArticleID:00020 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0950-2688 1469-4409 |
DOI: | 10.1017/S0950268810000208 |