Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 7; p. 1654
• Main Authors: Qiao, Xiaozhi, Li, Yunlan, Mai, Jiaqi, Ji, Xiaoqing, Li, Qingshan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.07.2018; MDPI
• Subjects: Cell Line; Cell Survival - drug effects; dibutyltin dilaurate (DBTD); Dose-Response Relationship, Drug; Gene Expression Regulation - drug effects; Hepatocytes - cytology; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Kinases; Lipid Metabolism - drug effects; Metabolism; mTOR pathway; Organotin Compounds - pharmacology; Phosphorylation - drug effects; PPAR alpha - genetics; PPARα; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Signal Transduction - drug effects; Sirolimus - pharmacology; SREBP1C; Sterol Regulatory Element Binding Protein 1 - genetics; TOR Serine-Threonine Kinases - metabolism; Triglycerides - metabolism; SREBP1C; mTOR pathway; triglycerides metabolism; dibutyltin dilaurate (DBTD); PPARα

Dibutyltin dilaurate (DBTD) has multiple applications in daily life. However, DBTD is easily deposited in the liver and affects liver functions. This study was designed to explore the effects of DBTD on triglyceride metabolism in human normal hepatocyte HL7702 cells. Our results showed that the intr...