A switch from epithelial to mesenchymal properties correlates with lymphovascular invasion in squamous cell carcinoma of the penis

• Published in: Pathology, research and practice Vol. 211; no. 9; pp. 641 - 645
• Main Authors: May, Matthias, Brookman-May, Sabine, Burger, Maximilian, Koch, Stefan, Otto, Wolfgang, Bründl, Johannes, Albrecht, Knut, Denzinger, Stefan
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.09.2015
• Subjects: Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; Blood Vessels - pathology; Cadherin switch; Cadherins - analysis; Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Epithelial-Mesenchymal Transition; Epithelial-to-mesenchymal transition; Germany; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphatic Vessels - pathology; Lymphovascular invasion; Male; Middle Aged; Neoplasm Invasiveness; Observer Variation; Penile Neoplasms - chemistry; Penile Neoplasms - mortality; Penile Neoplasms - pathology; Penile Neoplasms - surgery; Predictive Value of Tests; Proportional Hazards Models; Reproducibility of Results; Retrospective Studies; Squamous cell carcinoma of the penis; Targeted therapies; Time Factors; Treatment Outcome; Vimentin - analysis; Germany; Immunohistochemistry; Targeted therapies; Squamous cell carcinoma of the penis; Cadherin switch; Epithelial-to-mesenchymal transition; Lymphovascular invasion

The purpose of the study was to assess the incidence and prognostic role of epithelial-to-mesenchymal-transition (EMT) in squamous cell carcinoma of the penis (SCCP). Sixty tumor specimens of surgically treated SCCP patients characterized by a central histopathologic review were stained with antibod...