Reversible EMT and MET mediate amnion remodeling during pregnancy and labor

• Published in: Science signaling Vol. 13; no. 618
• Main Authors: Richardson, Lauren S, Taylor, Robert N, Menon, Ramkumar
• Format: Journal Article
• Language: English
• Published: United States 11.02.2020
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Amnion - cytology; Amnion - metabolism; Amnion - ultrastructure; Animals; Cells, Cultured; Epithelial Cells - metabolism; Epithelial-Mesenchymal Transition; Female; Gene Expression; Humans; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mesenchymal Stem Cells - metabolism; Mice; Microscopy, Electron, Transmission; Oxidative Stress; p38 Mitogen-Activated Protein Kinases - metabolism; Parturition; Pregnancy; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; Transforming Growth Factor beta1 - metabolism

The amnion is remodeled during pregnancy to protect the growing fetus it contains, and it is particularly dynamic just before and during labor. By combining ultrastructural, immunohistochemical, and Western blotting analyses, we found that human and mouse amnion membranes during labor were subject t...