The Potential of Dietary Bioactive Compounds against SARS-CoV-2 and COVID-19-Induced Endothelial Dysfunction

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 5; p. 1623
• Main Author: Losso, Jack N.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2022; MDPI
• Subjects: Aging; Alzheimer's disease; Atherosclerosis; Bioavailability; Blood pressure; Blood vessels; Cardiovascular disease; Cell adhesion & migration; COVID-19; COVID-19 - drug therapy; COVID-19 - pathology; COVID-19 - virology; Cytokines; Diabetes; Endothelium; Endothelium - drug effects; Endothelium - metabolism; endothelium dysfunction; Enzymes; Flavonoids - metabolism; Flavonoids - pharmacology; Flavonoids - therapeutic use; food bioactives; Free radicals; Functional Food - analysis; functional foods; Humans; Hyperglycemia; Hypertension; Infections; Lipoproteins; Metabolism; Oxidative stress; Pathogenesis; Permeability; Physiology; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; Review; Risk Factors; SARS-CoV-2; SARS-CoV-2 - drug effects; SARS-CoV-2 - isolation & purification; Smoking; Stilbenes - pharmacology; Stilbenes - therapeutic use; Terpenes - pharmacology; Terpenes - therapeutic use; COVID-19; functional foods; SARS-CoV-2; food bioactives; endothelium dysfunction

COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with...