The Potential of Dietary Bioactive Compounds against SARS-CoV-2 and COVID-19-Induced Endothelial Dysfunction

COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 5; p. 1623
Main Author Losso, Jack N.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2022
MDPI
Subjects
Aging
Alzheimer's disease
Atherosclerosis
Bioavailability
Blood pressure
Blood vessels
Cardiovascular disease
Cell adhesion & migration
COVID-19
COVID-19 - drug therapy
COVID-19 - pathology
COVID-19 - virology
Cytokines
Diabetes
Endothelium
Endothelium - drug effects
Endothelium - metabolism
endothelium dysfunction
Enzymes
Flavonoids - metabolism
Flavonoids - pharmacology
Flavonoids - therapeutic use
food bioactives
Free radicals
Functional Food - analysis
functional foods
Humans
Hyperglycemia
Hypertension
Infections
Lipoproteins
Metabolism
Oxidative stress
Pathogenesis
Permeability
Physiology
Polysaccharides - pharmacology
Polysaccharides - therapeutic use
Review
Risk Factors
SARS-CoV-2
SARS-CoV-2 - drug effects
SARS-CoV-2 - isolation & purification
Smoking
Stilbenes - pharmacology
Stilbenes - therapeutic use
Terpenes - pharmacology
Terpenes - therapeutic use
COVID-19
functional foods
SARS-CoV-2
food bioactives
endothelium dysfunction
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Abstract COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary preventions that address endothelial dysfunction and its sequelae may have an important role in preventing SARS-CoV-2 infection severity and are key factors for future research to address. This review presents some dietary bioactives with demonstrated efficacy against dysfunctional endothelial cells. This review also covers dietary bioactives with efficacy against SARS-CoV-2 infection. Dietary bioactive compounds that prevent endothelial dysfunction and its sequelae, especially in the gastrointestinal tract, will result in more effective prevention of SARS-CoV-2 variant infection severity and are key factors for future food research to address.
AbstractList COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary preventions that address endothelial dysfunction and its sequelae may have an important role in preventing SARS-CoV-2 infection severity and are key factors for future research to address. This review presents some dietary bioactives with demonstrated efficacy against dysfunctional endothelial cells. This review also covers dietary bioactives with efficacy against SARS-CoV-2 infection. Dietary bioactive compounds that prevent endothelial dysfunction and its sequelae, especially in the gastrointestinal tract, will result in more effective prevention of SARS-CoV-2 variant infection severity and are key factors for future food research to address.
COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary preventions that address endothelial dysfunction and its sequelae may have an important role in preventing SARS-CoV-2 infection severity and are key factors for future research to address. This review presents some dietary bioactives with demonstrated efficacy against dysfunctional endothelial cells. This review also covers dietary bioactives with efficacy against SARS-CoV-2 infection. Dietary bioactive compounds that prevent endothelial dysfunction and its sequelae, especially in the gastrointestinal tract, will result in more effective prevention of SARS-CoV-2 variant infection severity and are key factors for future food research to address.COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary preventions that address endothelial dysfunction and its sequelae may have an important role in preventing SARS-CoV-2 infection severity and are key factors for future research to address. This review presents some dietary bioactives with demonstrated efficacy against dysfunctional endothelial cells. This review also covers dietary bioactives with efficacy against SARS-CoV-2 infection. Dietary bioactive compounds that prevent endothelial dysfunction and its sequelae, especially in the gastrointestinal tract, will result in more effective prevention of SARS-CoV-2 variant infection severity and are key factors for future food research to address.
Author Losso, Jack N.
AuthorAffiliation School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, LA 70803, USA; jlosso@agcenter.lsu.edu
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35268723$$D View this record in MEDLINE/PubMed
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Keywords COVID-19
functional foods
SARS-CoV-2
food bioactives
endothelium dysfunction
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Snippet COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age,...
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SubjectTerms Aging
Alzheimer's disease
Atherosclerosis
Bioavailability
Blood pressure
Blood vessels
Cardiovascular disease
Cell adhesion & migration
COVID-19
COVID-19 - drug therapy
COVID-19 - pathology
COVID-19 - virology
Cytokines
Diabetes
Endothelium
Endothelium - drug effects
Endothelium - metabolism
endothelium dysfunction
Enzymes
Flavonoids - metabolism
Flavonoids - pharmacology
Flavonoids - therapeutic use
food bioactives
Free radicals
Functional Food - analysis
functional foods
Humans
Hyperglycemia
Hypertension
Infections
Lipoproteins
Metabolism
Oxidative stress
Pathogenesis
Permeability
Physiology
Polysaccharides - pharmacology
Polysaccharides - therapeutic use
Review
Risk Factors
SARS-CoV-2
SARS-CoV-2 - drug effects
SARS-CoV-2 - isolation & purification
Smoking
Stilbenes - pharmacology
Stilbenes - therapeutic use
Terpenes - pharmacology
Terpenes - therapeutic use
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Title The Potential of Dietary Bioactive Compounds against SARS-CoV-2 and COVID-19-Induced Endothelial Dysfunction
URI https://www.ncbi.nlm.nih.gov/pubmed/35268723
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Volume 27
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