Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 18; no. 1; pp. 178 - 188
• Main Authors: Eagle, Dawn M., Baunez, Christelle, Hutcheson, Daniel M., Lehmann, Olivia, Shah, Aarti P., Robbins, Trevor W.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2008; Oxford Publishing Limited (England); Oxford University Press (OUP)
• Subjects: Animals; Attention - physiology; Choice Behavior - physiology; infralimbic cortex; Inhibition, Psychological; Life Sciences; Male; Neurons and Cognition; orbitofrontal cortex; prefrontal cortex; Prefrontal Cortex - physiology; Rats; Reaction Time - physiology; response inhibition; Set, Psychology; stop-signal reaction time; subthalamic nucleus; Subthalamic Nucleus - physiology; Task Performance and Analysis; orbitofrontal cortex; stop-signal reaction time; infralimbic cortex; prefrontal cortex; subthalamic nucleus; response inhibition
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhm044

The stop-signal reaction-time (SSRT) task measures inhibition of a response that has already been initiated, that is, the ability to stop. Human subjects classified as “impulsive,” for example, those with attention deficit and hyperactivity disorder, are slower to respond to the stop signal. Althoug...