Design, Synthesis and Biological Evaluation of Novel Thienylpyridyl- and Thioether-Containing Acetamides and Their Derivatives as Pesticidal Agents

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 18; p. 5649
• Main Authors: Li, Huan, Yang, Na, Xiong, Lixia, Wang, Baolei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.09.2021; MDPI
• Subjects: Acetamides - chemical synthesis; Acetamides - chemistry; Acetamides - pharmacology; Animals; Ascomycota; Chemistry; Design; Drug Design; Insecticides; Insecticides - chemical synthesis; Insecticides - chemistry; Insecticides - pharmacology; Molecular Structure; Moths - drug effects; Optimization; pesticidal activity; Pesticides - chemical synthesis; Pesticides - chemistry; Pesticides - pharmacology; Structure-Activity Relationship; Sulfides - chemical synthesis; Sulfides - chemistry; Sulfides - pharmacology; sulfone; synthesis; thienylpyridylthioacetamide; thioether; synthesis; thienylpyridylthioacetamide; pesticidal activity; thioether; sulfone

Referring to the structural information of the “hit” compound A from the reported pharmacophore-based virtual screening, a series of novel thienylpyridyl- and thioether/sulfoxide/sulfone-containing acetamide derivatives have been designed and synthesized. The structures of new compounds were confirm...