Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions

• Published in: Frontiers in molecular neuroscience Vol. 15; p. 839366
• Main Authors: Zourray, Clara, Kurian, Manju A, Barral, Serena, Lignani, Gabriele
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 16.02.2022; Frontiers Media S.A
• Subjects: Brain stem; cortical organoids; electrophysiology; Epilepsy; network activity; neurodevelopmental disorders; neuronal maturation; Neuroscience; Organoids; Physiology; Stem cells; network activity; neuronal maturation; electrophysiology; neurodevelopmental disorders; cortical organoids

Human cortical development is an intricate process resulting in the generation of many interacting cell types and long-range connections to and from other brain regions. Human stem cell-derived cortical organoids are now becoming widely used to model human cortical development both in physiological...