Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions
Human cortical development is an intricate process resulting in the generation of many interacting cell types and long-range connections to and from other brain regions. Human stem cell-derived cortical organoids are now becoming widely used to model human cortical development both in physiological...
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Published in | Frontiers in molecular neuroscience Vol. 15; p. 839366 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
16.02.2022
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | Human cortical development is an intricate process resulting in the generation of many interacting cell types and long-range connections to and from other brain regions. Human stem cell-derived cortical organoids are now becoming widely used to model human cortical development both in physiological and pathological conditions, as they offer the advantage of recapitulating human-specific aspects of corticogenesis that were previously inaccessible. Understanding the electrophysiological properties and functional maturation of neurons derived from human cortical organoids is key to ensure their physiological and pathological relevance. Here we review existing data on the electrophysiological properties of neurons in human cortical organoids, as well as recent advances in the complexity of cortical organoid modeling that have led to improvements in functional maturation at single neuron and neuronal network levels. Eventually, a more comprehensive and standardized electrophysiological characterization of these models will allow to better understand human neurophysiology, model diseases and test novel treatments. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Ashwin S. Shetty, Harvard University, United States; Jinsoo Seo, Daegu Gyeongbuk Institute of Science and Technology (DGIST), South Korea These authors share last authorship Edited by: Hyunsoo Shawn Je, Duke-NUS Medical School, Singapore This article was submitted to Brain Disease Mechanisms, a section of the journal Frontiers in Molecular Neuroscience |
ISSN: | 1662-5099 1662-5099 |
DOI: | 10.3389/fnmol.2022.839366 |