Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial

• Published in: The American journal of clinical nutrition Vol. 108; no. 5; pp. 1026 - 1033
• Main Authors: Park, Yongsoon, Choi, Jeong-Eun, Hwang, Hwan-Sik
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018; Oxford University Press; American Society for Clinical Nutrition, Inc
• Subjects: adults at risk; adverse effects; Age; Aged; Aged, 80 and over; Body Composition; Body mass; body mass index; clinical trial; Clinical trials; Dietary Proteins - administration & dosage; Dietary Proteins - pharmacology; Dietary Supplements; dose response; Dose-Response Relationship, Drug; Double-Blind Method; Double-blind studies; Dual energy X-ray absorptiometry; elderly; Energy measurement; exercise; Female; Frail Elderly; Frailty; Gait; Geriatrics; Humans; Male; Malnutrition; Malnutrition - complications; Malnutrition - metabolism; Motivation; Muscle function; muscle mass; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscles; Nutrition; Nutrition Assessment; Nutritional Status; Older people; Physical fitness; Physical Functional Performance; protein intake; protein supplementation; protein supplements; Proteins; Randomization; randomized clinical trials; Sarcopenia; Sarcopenia - drug therapy; Sarcopenia - metabolism; Sarcopenia - prevention & control; Skeletal muscle; Weight; clinical trial; MNA; elderly; TUG; ITT; SPPB; SMI; CHS; muscle mass; frailty; malnutrition; KLo SHA; BUN; protein supplementation; ASM

Age-related loss of muscle mass and function is a major component of frailty. Nutrition supplementation with exercise is an effective strategy to decrease frailty by preventing sarcopenia, but the effect of protein alone is controversial. The present study was performed to investigate a dose-depende...