Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment
We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complicatio...
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| Published in | Molecules (Basel, Switzerland) Vol. 24; no. 7; p. 1219 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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28.03.2019
MDPI |
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| Online Access | Get full text |
| ISSN | 1420-3049 1420-3049 |
| DOI | 10.3390/molecules24071219 |
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| Abstract | We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complication in PAD, which affects a significant percentage of the elderly population. While studies on inducing angiogenesis to treat PAD were started two decades ago, early results from animal models as well as clinical trials have not yet been translated into clinical practice. We examine some of the challenges encountered during such translation. We further note the need for sustained angiogenic effect involving whole growth factor, gene therapy and synthetic growth factor strategies. Finally, we discuss the need for tissue depots for de novo formation of microvasculature. These scaffolds can act as templates for neovasculature development to improve circulation and healing at the preferred anatomical location. |
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| AbstractList | We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complication in PAD, which affects a significant percentage of the elderly population. While studies on inducing angiogenesis to treat PAD were started two decades ago, early results from animal models as well as clinical trials have not yet been translated into clinical practice. We examine some of the challenges encountered during such translation. We further note the need for sustained angiogenic effect involving whole growth factor, gene therapy and synthetic growth factor strategies. Finally, we discuss the need for tissue depots for de novo formation of microvasculature. These scaffolds can act as templates for neovasculature development to improve circulation and healing at the preferred anatomical location. We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complication in PAD, which affects a significant percentage of the elderly population. While studies on inducing angiogenesis to treat PAD were started two decades ago, early results from animal models as well as clinical trials have not yet been translated into clinical practice. We examine some of the challenges encountered during such translation. We further note the need for sustained angiogenic effect involving whole growth factor, gene therapy and synthetic growth factor strategies. Finally, we discuss the need for tissue depots for de novo formation of microvasculature. These scaffolds can act as templates for neovasculature development to improve circulation and healing at the preferred anatomical location.We describe progress and obstacles in the development of novel peptide-hydrogel therapeutics for unmet medical needs in ischemia treatment, focusing on the development and translation of therapies specifically in peripheral artery disease (PAD). Ischemia is a potentially life-threatening complication in PAD, which affects a significant percentage of the elderly population. While studies on inducing angiogenesis to treat PAD were started two decades ago, early results from animal models as well as clinical trials have not yet been translated into clinical practice. We examine some of the challenges encountered during such translation. We further note the need for sustained angiogenic effect involving whole growth factor, gene therapy and synthetic growth factor strategies. Finally, we discuss the need for tissue depots for de novo formation of microvasculature. These scaffolds can act as templates for neovasculature development to improve circulation and healing at the preferred anatomical location. |
| Author | Shi, Siyu Sarkar, Biplab Petrak, Karel Siddiqui, Zain Vissapragada, Ravi Kim, Ka Kyung Kumar, Vivek A. |
| AuthorAffiliation | 1 NangioTx Inc., Newark, NJ 07102, USA; petrak@nangiotx.com 2 Department of Gastrointestinal Surgery, Flinders Medical Centre, 5042 Bedford Park, South Australia, Australia; ravi.vissapragada@gmail.com 3 Department of Medicine Stanford School of Medicine, Stanford, CA 94305, USA; syshi@stanford.edu 5 Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA 4 Department of Biomedical Engineering, Newark, NJ 07102, USA; zs67@njit.edu (Z.S.); kk564@njit.edu (K.K.K.); bsarkar@njit.edu (B.S.) 6 Rutgers School of Dental Medicine, Newark, NJ 07103, USA |
| AuthorAffiliation_xml | – name: 2 Department of Gastrointestinal Surgery, Flinders Medical Centre, 5042 Bedford Park, South Australia, Australia; ravi.vissapragada@gmail.com – name: 3 Department of Medicine Stanford School of Medicine, Stanford, CA 94305, USA; syshi@stanford.edu – name: 6 Rutgers School of Dental Medicine, Newark, NJ 07103, USA – name: 4 Department of Biomedical Engineering, Newark, NJ 07102, USA; zs67@njit.edu (Z.S.); kk564@njit.edu (K.K.K.); bsarkar@njit.edu (B.S.) – name: 5 Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA – name: 1 NangioTx Inc., Newark, NJ 07102, USA; petrak@nangiotx.com |
| Author_xml | – sequence: 1 givenname: Karel orcidid: 0000-0002-8850-2114 surname: Petrak fullname: Petrak, Karel – sequence: 2 givenname: Ravi orcidid: 0000-0001-5372-7674 surname: Vissapragada fullname: Vissapragada, Ravi – sequence: 3 givenname: Siyu orcidid: 0000-0001-9010-7431 surname: Shi fullname: Shi, Siyu – sequence: 4 givenname: Zain surname: Siddiqui fullname: Siddiqui, Zain – sequence: 5 givenname: Ka Kyung surname: Kim fullname: Kim, Ka Kyung – sequence: 6 givenname: Biplab surname: Sarkar fullname: Sarkar, Biplab – sequence: 7 givenname: Vivek A. orcidid: 0000-0001-7536-9281 surname: Kumar fullname: Kumar, Vivek A. |
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| CitedBy_id | crossref_primary_10_1186_s40580_019_0209_y crossref_primary_10_1016_j_bioactmat_2020_01_005 crossref_primary_10_1016_j_bioactmat_2021_11_015 crossref_primary_10_1016_j_sdentj_2024_06_005 crossref_primary_10_3390_molecules24173089 crossref_primary_10_1007_s10456_020_09714_0 |
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| Copyright | 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 by the authors. 2019 |
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| SubjectTerms | Adenoviruses Amputation Angiogenesis Angiogenic Proteins - therapeutic use Animals Atherosclerosis Biodistribution Clinical trials Communication development Disease Models, Animal Drug Discovery Drug therapy Fibroblasts Gene expression Growth factors Humans Ischemia Ischemia - drug therapy Neovascularization, Physiologic - drug effects Patients peptide Pharmacokinetics Success therapeutic translation Translational Research, Biomedical Ulcers |
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| Title | Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment |
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