A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 11; p. 3419
• Main Authors: Chamakuri, Srinivas, Tang, Sunny Ann, Tran, Kevin A, Guduru, Shiva Krishna Reddy, Bolin, Peter K, MacKenzie, Kevin R, Young, Damian W
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2022; MDPI
• Subjects: 2,3-substituted piperazines; Acetic acid; Amino acids; annulation; Carbon; chiral piperazines; Chromatography; diamine; Diamines; Esters; masamune condensation; Piperazine; Substitutes; diamine; annulation; masamune condensation; 2,3-substituted piperazines; chiral piperazines

We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel r...