In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 6; p. 1295
• Main Authors: Saeki, Koichi, Hayakawa, Sumio, Nakano, Shogo, Ito, Sohei, Oishi, Yumiko, Suzuki, Yasuo, Isemura, Mamoru
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.05.2018; MDPI
• Subjects: affinity chromatography; binding interaction; cancer; catechin; Catechin - analogs & derivatives; Catechin - chemistry; Catechin - pharmacology; Computer Simulation; Crystallography, X-Ray; Drug Design; EGCG; epidemiology; green tea; health benefits; Humans; In Vitro Techniques; Models, Molecular; molecular docking; Molecular Docking Simulation; protein; Proteins; Proteins - chemistry; Proteins - metabolism; Review; Surface Plasmon Resonance; Tea; Tea - chemistry; affinity chromatography; epidemiology; molecular docking; EGCG; protein; green tea; catechin; cancer; health benefits; binding interaction

Green tea has been shown to have beneficial effects on many diseases such as cancer, obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea component, epigallocatechin-3-O-gallate (EGCG), has been demonstrated to contribute to these effects through its anti-oxidative an...