The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

• Published in: Critical reviews in food science and nutrition Vol. 62; no. 3; pp. 832 - 859
• Main Authors: Farha, Arakkaveettil Kabeer, Gan, Ren-You, Li, Hua-Bin, Wu, Ding-Tao, Atanasov, Atanas G., Gul, Khalid, Zhang, Jia-Rong, Yang, Qiong-Qiong, Corke, Harold
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2022; Taylor & Francis Ltd
• Subjects: Angiogenesis; Animals; Anticancer activity; Anticancer properties; antineoplastic agents; Antineoplastic Agents - therapeutic use; Antioxidants - therapeutic use; Antitumor agents; Apoptosis; Autophagy; Bioavailability; Cancer; Carcinogenesis; Carcinogens; Cell cycle; Cell proliferation; chemoprevention; Chemotherapy; Cytokines; dietary polyphenol; Dietary supplements; drug therapy; food science; Functional foods & nutraceuticals; Humans; Inflammation; Intestinal microflora; intestinal microorganisms; Intestine; Kinases; mammals; metabolism; Metabolites; Metastases; metastasis; Microbiota; nanoparticle; Neoplasms - drug therapy; Neoplasms - prevention & control; phosphotransferases (kinases); Plants (botany); Polyphenols; Polyphenols - pharmacology; Polyphenols - therapeutic use; Reactive oxygen species; Reagents; Rutin; Rutin - therapeutic use; safety; Transcription factors; dietary polyphenol; nanoparticle; metabolism; rutin; safety; Anticancer activity

Rutin is one of the most common dietary polyphenols found in vegetables, fruits, and other plants. It is metabolized by the mammalian gut microbiota and absorbed from the intestines, and becomes bioavailable in the form of conjugated metabolites. Rutin exhibits a plethora of bioactive properties, ma...