Contribution of Acquired Factors to the Pathogenesis of Dilated Cardiomyopathy The Cause of Dilated Cardiomyopathy: Genetic or Acquired? (Acquired-Side)

• Published in: Circulation Journal Vol. 75; no. 7; pp. 1766 - 1773
• Main Author: Yoshikawa, Tsutomu
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2011
• Subjects: Antibodies; Cardiomyopathy, Dilated - genetics; Cytokines; Dilated cardiomyopathy; Disease Susceptibility; Genetics; Humans; Immune system; Mutation - genetics; Myocarditis

Although genetic abnormalities play a pivotal role in the development of dilated cardiomyopathy (DCM), acquired infection and autoimmune abnormalities, or both, appear to be predominant underlying disorders. Of these, viral infection causes target organ damage via perforin produced by suppressor T c...