Invasion of Epithelial Cells and Proteolysis of Cellular Focal Adhesion Components by Distinct Types of Porphyromonas gingivalis Fimbriae

• Published in: Infection and Immunity Vol. 74; no. 7; pp. 3773 - 3782
• Main Authors: Nakagawa, Ichiro, Inaba, Hiroaki, Yamamura, Taihei, Kato, Takahiro, Kawai, Shinji, Ooshima, Takashi, Amano, Atsuo
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2006
• Subjects: Adhesins, Bacterial - metabolism; Biological and medical sciences; Cellular Microbiology: Pathogen-Host Cell Molecular Interactions; Cysteine Endopeptidases - metabolism; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Fimbriae, Bacterial - enzymology; Fimbriae, Bacterial - physiology; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Focal Adhesions - metabolism; Fundamental and applied biological sciences. Psychology; HeLa Cells; Humans; Hydrolysis; Microbiology; Paxillin - metabolism; Porphyromonas gingivalis; Porphyromonas gingivalis - enzymology; Porphyromonas gingivalis - pathogenicity; Porphyromonas gingivalis; Microbiology; Proteolysis; Bacteria; Epithelial cell; Pilus; Adhesion; Immunity; Bacteroidaceae

Porphyromonas gingivalis fimbriae are classified into six types (types I to V and Ib) based on the fimA genes encoding FimA (a subunit of fimbriae), and they play a critical role in bacterial interactions with host tissues. In this study, we compared the efficiencies of P. gingivalis strains with di...