Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy

• Published in: Orphanet journal of rare diseases Vol. 15; no. 1; p. 65
• Main Authors: Pesl, Martin, Jelinkova, Sarka, Caluori, Guido, Holicka, Maria, Krejci, Jan, Nemec, Petr, Kohutova, Aneta, Zampachova, Vita, Dvorak, Petr, Rotrekl, Vladimir
• Format: Journal Article
• Language: English
• Published: England BioMed Central 05.03.2020; BMC
• Subjects: Age; Becker muscular dystrophy; Becker's muscular dystrophy; C-kit; Cardiomyocytes; Cardiomyopathy; Cardiovascular diseases; Cardiovascular progenitor cells; Cell adhesion & migration; Coronary vessels; Dystrophin; Fibroblasts; Heart failure; Kinases; Medical research; Muscular dystrophy; Musculoskeletal system; Mutation; Myocardium; Organ donors; Patients; Progenitor cells; Rare diseases; Stem cells; Transplants & implants; Veins & arteries; Heart failure; Becker muscular dystrophy; C-kit; Cardiomyopathy; Cardiovascular progenitor cells; Dystrophin

We describe the association of Becker muscular dystrophy (BMD) derived heart failure with the impairment of tissue homeostasis and remodeling capabilities of the affected heart tissue. We report that BMD heart failure is associated with a significantly decreased number of cardiovascular progenitor c...