SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men

• Published in: BMC medical genetics Vol. 18; no. 1; pp. 41 - 5
• Main Authors: Hirvonen, Katariina, Laivuori, Hannele, Lahti, Jari, Strandberg, Timo, Eriksson, Johan G., Hackman, Peter
• Format: Journal Article
• Language: English
• Published: England BioMed Central 11.04.2017; BMC
• Subjects: Activities of daily living; Age; Aging; Alleles; Case-Control Studies; Cell cycle; Chronic illnesses; Cohort Studies; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - isolation & purification; DNA - metabolism; DNA repair; DNA structure; Exons; Finland; Gene Frequency; Genetic markers; Genomes; Heterozygosity; Heterozygote; Homeostasis; Humans; Insulin-like growth factors; Longevity; Longevity - genetics; Male; Mens health; Mental health; Metabolism; NF-κB protein; Odds Ratio; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Rodents; Senescence; Sequence Analysis, DNA; Single-nucleotide polymorphism; SIRT6; Sirtuins - genetics; Stem cells; Studies; Transcription; Aging; SIRT6; Longevity; Polymorphism

Sirtuin-6 (SIRT6) is involved in various crucial cellular pathways, being a key regulator of telomere structure, DNA repair, metabolism, transcriptional control and the NF-kappa B pathway. Sirt6 knock-out mice have been reported to develop typical features of aging and senescence at the age of 2-3 w...