Bifidobacterium species serve as key gut microbiome regulators after intervention in gestational diabetes mellitus

• Published in: BMC microbiology Vol. 24; no. 1; pp. 520 - 17
• Main Authors: Cui, Zifeng, Wang, Shuxian, Niu, Jianhua, Ma, Jingmei, Yang, Huixia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.12.2024; BioMed Central; BMC
• Subjects: Adult; Analysis; Bacteria; Bifidobacterium; Bifidobacterium - genetics; Care and treatment; Cell surface; Chemoreception; Complications and side effects; Composition; Control; Diabetes in pregnancy; Diabetes mellitus; Diabetes, Gestational - blood; Diabetes, Gestational - metabolism; Diabetes, Gestational - microbiology; Digestive system; Dysbacteriosis; Dysbiosis - microbiology; Exercise; Fatty Acids, Volatile - metabolism; Feces; Feces - microbiology; Female; Functional analysis; Gastrointestinal Microbiome - genetics; Gastrointestinal tract; Genome-wide association studies; Genome-Wide Association Study; Genomes; Gestational diabetes; Gestational diabetes mellitus; Glucose; Glucose tolerance; Glucose tolerance tests; Glycemic control; Gram-negative bacteria; Gut microbiome regulator; Gut microbiota; Homeostasis; Hospitals; Humans; Hyperglycemia; Hypoglycemia; Identification and classification; Intervention; Intestinal microflora; Lifestyles; Medical nutrition therapy; Medical records; Mendelian randomization; Metabolism; Metagenome; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Nutrition; Patient outcomes; Phylogenetics; Plasma; Pregnancy; Pregnancy complications; Quality control; Risk factors; China; United States > US; Germany; Glycemic control; Gestational diabetes mellitus; Bifidobacterium; Gut microbiome regulator; Mendelian randomization

Gut microbiome dysbiosis is associated with gestational diabetes mellitus (GDM), and its modulation represents a promising approach for enhancing glycemic control. In this study, we aimed to discover specific alterations in the gut microbiome through lifestyle management. We performed metagenome seq...