Multiple Neuroendocrine Tumors in Stomach and Duodenum in a Multiple Endocrine Neoplasia Type 1 Patient

• Published in: Journal of pathology and translational medicine Vol. 52; no. 2; pp. 126 - 129
• Main Authors: Kim, Bohyun, Yang, Han-Kwang, Kim, Woo Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Pathologists and the Korean Society for Cytopathology 01.03.2018; Korean Society of Pathologists & the Korean Society for Cytopathology; 대한병리학회
• Subjects: Case Study; Histologic mapping; Multiple endocrine neoplasia type 1; Neuroendocrine tumors; Stomach neoplasms; 병리학; Multiple endocrine neoplasia type 1; Histologic mapping; Stomach neoplasms; Neuroendocrine tumors
• ISSN: 2383-7837; 2383-7845
• DOI: 10.4132/jptm.2017.09.16

A 67-year-old woman with a history of subtotal parathyroidectomy, distal pancreatectomy, and total splenectomy 23 years prior underwent surgical gastric resection for neuroendocrine tumors of the stomach and duodenum. Meticulous examination of the entire stomach and duodenum revealed multiple scattered, minute neuroendocrine tumors. To the best of our knowledge, this is the first case report of a patient diagnosed with gastroduodenal neuroendocrine tumors associated with multiple endocrine neoplasia type 1 (MEN 1) in whom complete histologic mapping of the whole gastrectomy specimen was performed. The presence of MEN 1-associated neuroendocrine tumors in the stomach is very rare, but should be considered in patients diagnosed with MEN 1 who present with a new tumor in the stomach.