S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells - Fan, Yuqi; Mao, Yiwei; Cao, Shijie; Xia, Guiyang; Zhang, Qiang; Zhang, Hongyang; Qiu, Feng; Kang, Ning (Molecules (Basel, Switzerland), 2018)
Keywords: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis; Autophagy; Binding sites; Cell cycle; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; Cyclin-dependent kinases; EGFR; ErbB Receptors - metabolism; Flow cytometry; G2 Phase Cell Cycle Checkpoints - drug effects; G2/M arrest; Homeostasis; Humans; Kidney cancer; Kinases; Medical prognosis; Melanoma; Molecular Structure; P38; p38 Mitogen-Activated Protein Kinases - metabolism; Physalis - chemistry; Proteins; Signal transduction; Signal Transduction - drug effects; Skin cancer; Withanolides - chemistry; Withanolides - isolation & purification; Withanolides - pharmacology; melanoma; S5; P38; G2/M arrest; EGFR