The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance

• Published in: The Journal of immunology (1950) Vol. 187; no. 9; pp. 4530 - 4541
• Main Authors: D’Addio, Francesca, Riella, Leonardo V, Mfarrej, Bechara G, Chabtini, Lola, Adams, La Tonya, Yeung, Melissa, Yagita, Hideo, Azuma, Miyuki, Sayegh, Mohamed H, Guleria, Indira
• Format: Journal Article
• Language: English
• Published: England 01.11.2011
• Subjects: Animals; Antigens, Differentiation - physiology; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - physiology; Female; Gene Knock-In Techniques; Histocompatibility Antigens Class II - genetics; Histocompatibility Antigens Class II - physiology; Histocompatibility, Maternal-Fetal - genetics; Histocompatibility, Maternal-Fetal - immunology; Immune Tolerance - genetics; Interleukin-17 - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pregnancy; Programmed Cell Death 1 Receptor - physiology; Signal Transduction - immunology; Th1 Cells - immunology; Th1 Cells - metabolism; Th17 Cells - cytology; Th17 Cells - immunology; Th17 Cells - metabolism; Th2 Cells - immunology; Th2 Cells - metabolism
• ISSN: 0022-1767; 1550-6606; 1550-6606
• DOI: 10.4049/jimmunol.1002031

Fetomaternal tolerance has been shown to depend both on regulatory T cells (Tregs) and negative signals from the PD1–PDL1 costimulatory pathway. More recently, IL-17–producing T cells (Th17) have been recognized as a barrier in inducing tolerance in transplantation. In this study, we investigate the...