Detection of 13 Ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rh2, F1, Compound K, 20(S)-Protopanaxadiol, and 20(S)-Protopanaxatriol) in Human Plasma and Application of the Analytical Method to Human Pharmacokinetic Studies Following Two Week-Repeated Administration of Red Ginseng Extract

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 14; p. 2618
• Main Authors: Jin, Sojeong, Jeon, Ji-Hyeon, Lee, Sowon, Kang, Woo Youl, Seong, Sook Jin, Yoon, Young-Ran, Choi, Min-Koo, Song, Im-Sook
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.07.2019; MDPI
• Subjects: Accuracy; Bioavailability; Calibration; Chromatography; ginsenosides; Ginsenosides - blood; Ginsenosides - chemistry; Ginsenosides - pharmacokinetics; human; Human subjects; Humans; Mass spectrometry; Metabolic Networks and Pathways; Metabolites; Methods; Molecular Structure; Oral administration; Panax - chemistry; Pharmacokinetics; Plant Extracts - blood; Plant Extracts - chemistry; Plant Extracts - pharmacokinetics; Plasma; Proteins; red ginseng extract; Reproducibility of Results; Retention; Scientific imaging; Sensitivity and Specificity; Tandem Mass Spectrometry; pharmacokinetics; ginsenosides; human; red ginseng extract

We aimed to develop a sensitive method for detecting 13 ginsenosides using liquid chromatography–tandem mass spectrometry and to apply this method to pharmacokinetic studies in human following repeated oral administration of red ginseng extract. The chromatograms of Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg...