Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation

• Published in: Clinical epigenetics Vol. 9; no. 1; pp. 43 - 9
• Main Authors: Tremblay, Bénédicte L., Guénard, Frédéric, Rudkowska, Iwona, Lemieux, Simone, Couture, Patrick, Vohl, Marie-Claude
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central 26.04.2017; BMC
• Subjects: Adult; Age; Blood; Blood leukocytes; Body mass index; Body weight; Cardiovascular diseases; Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Cholesterol; CpG Islands; Deoxyribonucleic acid; Diabetes mellitus; Dietary Supplements; DNA; DNA - blood; DNA - drug effects; DNA methylation; DNA Methylation - drug effects; Epigenesis, Genetic - drug effects; Epigenetics; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - pharmacology; Female; Gene Expression Regulation - drug effects; Gene Regulatory Networks - drug effects; Genes; Genomes; High density lipoprotein; Humans; Hypertension; Immune response; Inflammation; Insulin-like growth factor-binding protein 5; Kinases; Leukocytes; Leukocytes - chemistry; Leukocytes - drug effects; Lipid metabolism; Localization; Low density lipoprotein; Male; Mens health; Metabolic Networks and Pathways - drug effects; Metabolic pathways; Metabolism; Microarray; Obesity - blood; Obesity - complications; Obesity - diet therapy; Obesity - genetics; Omega-3 fatty acids; Overweight; Overweight - blood; Overweight - complications; Overweight - diet therapy; Overweight - genetics; Plasma; Polyunsaturated fatty acids; Proteins; Risk factors; Studies; Supplements; Transcription factors; DNA methylation; Metabolic pathways; Blood leukocytes; Microarray; Omega-3 fatty acids

Omega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigenetic modifications. Our objective is to investigate, using genome-wide DNA methylation analy...