Advanced pharmacodynamics of cangrelor in healthy volunteers: a dose-finding, open-label, pilot trial

• Published in: Thrombosis journal Vol. 20; no. 1; pp. 19 - 11
• Main Authors: Gelbenegger, Georg, Grafeneder, Juergen, Gager, Gloria M., Siller-Matula, Jolanta M., Schwameis, Michael, Jilma, Bernd, Schoergenhofer, Christian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.04.2022; BioMed Central; BMC
• Subjects: Adenosine diphosphate; Aggregation; Analysis; Blood clot; Blood platelets; Cangrelor; Electrodes; Epinephrine; Health aspects; Heart attack; Laboratories; Medical colleges; Mortality; Myocardial infarction; P2Y12; Pharmacodynamics; Pharmacokinetics; Phosphorylation; Platelet inhibition; Prehospital; Sample size; Thrombosis; Vasodilators; Myocardial infarction; Pharmacodynamics; Cangrelor; P2Y12; STEMI; Platelet inhibition; Prehospital

High on-treatment platelet reactivity (HTPR) remains a major problem in the acute management of ST-elevation myocardial infarction (STEMI), leading to higher rates of stent thrombosis and mortality. We aimed to investigate a novel, prehospital treatment strategy using cangrelor and tested its pharma...