High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model

• Published in: Nano today Vol. 8; no. 2; pp. 126 - 137
• Main Authors: Smith, Bryan Ronain, Zavaleta, Cristina, Rosenberg, Jarrett, Tong, Ricky, Ramunas, John, Liu, Zhuang, Dai, Hongjie, Gambhir, Sanjiv Sam
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2013; Elsevier
• Subjects: Cancer; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Intravital microscopy; Materials science; Nanocrystalline materials; Nanoparticles; Nanoscale materials and structures: fabrication and characterization; Nanotubes; Physics; Serial imaging; Single-walled carbon nanotubes; Specificity; Targeting; Intravital microscopy; Nanoparticles; Specificity; Targeting; Serial imaging; Single-walled carbon nanotubes; Cancer; Peptides; Tumor cells; Glycine; Real time; Carbon; Singlewalled nanotube; Arginine; Tumours; Imaging; Ligands; Nanostructured materials; targeting; nanoparticles; serial imaging; single-walled carbon nanotubes; specificity; cancer

. [Display omitted] ► Quantitatively de-convoluted carbon nanotube targeting to tumors in live mice. ► Microscale visualization of targeting from injection to cell binding to clearance. ► Identified characteristic framework underlying nanoparticle targeting to tumors. ► Determined how targeting liga...