Chronic hypometabolism in striatum and hippocampal network after traumatic brain injury and their relation with memory impairment – [18F]-FDG-PET and MRI 4 months after fluid percussion injury in rat

• Published in: Brain research Vol. 1788; p. 147934
• Main Authors: Yasmin, Amna, Jokivarsi, Kimmo, Poutiainen, Pekka, Pitkänen, Asla, Gröhn, Olli, Immonen, Riikka
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2022
• Subjects: Brain trauma; Caudate putamen; Cerebral blood flow; Experimental TBI; Glucose uptake; Neurology; Positron emission tomography; Brain trauma; Glucose uptake; Caudate putamen; Cerebral blood flow; Experimental TBI; Positron emission tomography

[Display omitted] •Striatum has metabolic deficits in chronic stage after lateral fluid percussion injury.•[18F]-FDG-PET shows low glucose uptake across hippocampal network.•Striatal hypometabolism identifies rats with severe memory impairment.•MRI: Atrophy or cerebral blood flow do not correlate wi...