Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions[S]

• Published in: Journal of lipid research Vol. 54; no. 7; pp. 1798 - 1811
• Main Authors: Acosta-Rodríguez, Victoria A., Márquez, Sebastián, Salvador, Gabriela A., Pasquaré, Susana J., Gorné, Lucas D., Garbarino-Pico, Eduardo, Giusto, Norma M., Guido, Mario Eduardo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2013; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: 1-Acylglycerophosphocholine O-Acyltransferase - metabolism; Animals; Cells, Cultured; Choline Kinase - metabolism; Circadian Clocks; Circadian Rhythm; Fibroblasts - cytology; Fibroblasts - enzymology; Fibroblasts - metabolism; Glycerophospholipids - biosynthesis; Mice; NIH 3T3 Cells; Pancreatitis-Associated Proteins; Phosphatidate Phosphatase - metabolism; phospholipid; serum shock; synchronization; synchronization; serum shock; phospholipid; circadian rhythm

Circadian clocks regulate the temporal organization of several biochemical processes, including lipid metabolism, and their disruption leads to severe metabolic disorders. Immortalized cell lines acting as circadian clocks display daily variations in [32P]phospholipid labeling; however, the regulati...