Evaluation of Two Potent and Selective PET Radioligands to Image COX-1 and COX-2 in Rhesus Monkeys - Kim, Min-Jeong; Shrestha, Stal S.; Cortes, Michelle; Singh, Prachi; Morse, Cheryl; Liow, Jeih-San; Gladding, Robert L.; Brouwer, Chad; Henry, Katharine; Gallagher, Evan; Tye, George L.; Zoghbi, Sami S.; et al. (Journal of Nuclear Medicine, 2018)
Keywords: Animals; Brain; Carbon Radioisotopes; COX-2 inhibitors; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Cyclooxygenase-1; Cyclooxygenase-2; Female; Gastrointestinal system; Gastrointestinal tract; Infection/Inflammation; Inflammation; Intravenous administration; Kidneys; Macaca mulatta; Male; Monkeys; Organs; Ovaries; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Positron-Emission Tomography - veterinary; Pyrimidines - administration & dosage; Pyrimidines - chemistry; Pyrimidines - metabolism; Radioisotopes; Radioligand Assay; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacokinetics; Spleen; Tissue Distribution; Tomography; Triazoles - chemistry; Triazoles - pharmacokinetics; Whole Body Imaging - methods; Whole Body Imaging - veterinary; cyclooxygenase-1; positron-emission tomography; nonsteroidal antiinflammatory agents; inflammation; cyclooxygenase-2