Profiling of Amino Acids in Urine Samples of Patients Suffering from Inflammatory Bowel Disease by Capillary Electrophoresis-Mass Spectrometry

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 18; p. 3345
• Main Authors: Piestansky, Juraj, Olesova, Dominika, Galba, Jaroslav, Marakova, Katarina, Parrak, Vojtech, Secnik, Peter, Kovacech, Branislav, Kovac, Andrej, Zelinkova, Zuzana, Mikus, Peter
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.09.2019; MDPI
• Subjects: Adult; Amino acids; Amino Acids - urine; amino acids profiling; Biomarkers - urine; Capillary electrophoresis; capillary zone electrophoresis; Chromatography; clinical analysis; Electrolytes; Electrophoresis, Capillary; Female; human urine; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - urine; Limit of Detection; Male; Mass spectrometry; Metabolism; Middle Aged; NMR; Nuclear magnetic resonance; Polyamines; Reproducibility; Scientific imaging; Tandem Mass Spectrometry; Urine; capillary zone electrophoresis; mass spectrometry; amino acids profiling; human urine; clinical analysis; inflammatory bowel disease

Urine represents a convenient biofluid for metabolomic studies due to its noninvasive collection and richness in metabolites. Here, amino acids are valuable biomarkers for their ability to reflect imbalances of different biochemical pathways. An impact of amino acids on pathology, prognosis and ther...