Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 5; p. 1380
• Main Authors: Wu, Xiutao, Gong, Lijie, Chen, Chen, Tao, Ye, Zhou, Wuxi, Kong, Lingyi, Luo, Jianguang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.03.2021; MDPI
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; antiproliferative activity; Cancer; Cell Proliferation; Cytotoxicity; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Harringtonines - chemistry; harringtonolide; Humans; Molecular Structure; Natural products; Neoplasms - drug therapy; Structure-Activity Relationship; structure-activity relationship (SAR); troponoids; structure-activity relationship (SAR); harringtonolide; antiproliferative activity; troponoids

Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives. Modifications on tropone, lactone, and allyl positions...