Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa

• Published in: Journal of human genetics Vol. 59; no. 6; pp. 349 - 352
• Main Authors: Campbell, Michael C, Ranciaro, Alessia, Zinshteyn, Daniel, Rawlings-Goss, Renata, Hirbo, Jibril, Thompson, Simon, Woldemeskel, Dawit, Froment, Alain, Omar, Sabah A, Bodo, Jean-Marie, Nyambo, Thomas, Belay, Gurja, Drayna, Dennis, Breslin, Paul A S, Tishkoff, Sarah A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.06.2014
• Subjects: Africa, Eastern; Alleles; Anti-Inflammatory Agents - pharmacology; Benzyl Alcohols - pharmacology; Bitter taste; Chromosome 7; Evolution & development; Evolution, Molecular; Genetic Association Studies; Genotypes; Glucosides - pharmacology; Haplotypes; Humans; Inflammation; Phenotypes; Phenotypic variations; Polymorphism, Single Nucleotide; Population genetics; Population studies; Positive selection; Promoter Regions, Genetic; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Salicin; Statistical analysis; Taste; Taste perception; Taste Perception - genetics; Taste receptors; Africa, Eastern; East Africa

Bitter taste perception, mediated by receptors encoded by the TAS2R loci, has important roles in human health and nutrition. Prior studies have demonstrated that nonsynonymous variation at site 516 in the coding exon of TAS2R16, a bitter taste receptor gene on chromosome 7, has been subject to posit...