Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence

• Published in: Psychopharmacology Vol. 235; no. 3; pp. 849 - 859
• Main Authors: Zimmermann, Kaeli, Yao, Shuxia, Heinz, Marcel, Zhou, Feng, Dau, Wolfgang, Banger, Markus, Weber, Bernd, Hurlemann, René, Becker, Benjamin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2018; Springer; Springer Nature B.V
• Subjects: Abstinence; Adaptation; Addictions; Adolescent; Adult; Amygdala; Amygdala - physiopathology; Analysis of Variance; Arousal; Behavior, Addictive - physiopathology; Biomedical and Life Sciences; Biomedicine; Brain Mapping; Cannabis; Cannabis - adverse effects; Case-Control Studies; Cerebral Cortex - physiopathology; Cognitive ability; Drug legalization; Emotions; Emotions - physiology; Evidence-based medicine; Female; Frontal Lobe - physiopathology; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging; Male; Marijuana; Marijuana Abuse - physiopathology; Marijuana Abuse - psychology; Methods; Neostriatum; Neural networks; Neurosciences; Original Investigation; Pharmacology/Toxicology; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - physiopathology; Psychiatry; Psychological aspects; Psychopharmacology; Risk factors; Striatum; Substance abuse; Visual Cortex - physiopathology; Young Adult; fMRI; Striatum; Orbitofrontal cortex; Cannabis; Amygdala; Marijuana; Substance dependence; Emotion; Abstinence

Rationale Intact cognitive and emotional functioning is vital for the long-term success of addiction treatment strategies. Accumulating evidence suggests an association between chronic marijuana use and lasting alterations in cognitive brain function. Despite initial evidence for altered emotion pro...