Gelatin-Based Hydrogels through Homobifunctional Triazolinediones Targeting Tyrosine Residues

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 3; p. 589
• Main Authors: Guizzardi, Roberto, Vaghi, Luca, Marelli, Marcello, Natalello, Antonino, Andreosso, Ivan, Papagni, Antonio, Cipolla, Laura
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.02.2019; MDPI
• Subjects: Amino acids; Biomaterials; Biomedical materials; Biopolymers; chemical cross-linking; Chemistry; Crosslinking; cyclic diazodicarboxamides; Drug delivery; Drug delivery systems; Drug development; ene-type chemistry; Gelatin; Hexanes; hydrogel; Hydrogels; natural polymers; Proteins; Residues; Thermal stability; Tissue engineering; triazolinediones; Triazolines; Tyrosine; triazolinediones; natural polymers; ene-type chemistry; hydrogel; chemical cross-linking; cyclic diazodicarboxamides; tyrosine; gelatin

Gelatin is a biopolymer with interesting properties that can be useful for biomaterial design for different applications such as drug delivery systems, or 3D scaffolds for tissue engineering. However, gelatin suffers from poor mechanical stability at physiological temperature, hence methods for impr...