A complex barcode underlies the heterogeneous response of p53 to stress

• Published in: Nature reviews. Molecular cell biology Vol. 9; no. 9; pp. 702 - 712
• Main Authors: Lu, Xin, Murray-Zmijewski, Fiona, Slee, Elizabeth A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2008; Nature Publishing Group
• Subjects: Animals; Apoptosis; Bar codes; Biochemistry; Biomedical and Life Sciences; Cancer; Cancer Research; Cell Biology; Cell growth; Cellular signal transduction; Developmental Biology; Genes; Genetic aspects; Health aspects; Heterogeneity; Humans; Life Sciences; Medical research; Mutation; Organ Specificity; Physiology; Protein Transport; Proteins; review-article; Senescence; Stem Cells; Stress, Physiological - metabolism; Telomerase; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; United Kingdom

Key Points The tumour suppressor p53 is a master sensor of stress and integrates incoming signals to prevent malignant progression by inducing cellular responses such as apoptosis and senescence. The response to p53 activation is heterogeneous and depends on the nature and intensity of the activatin...