A complex barcode underlies the heterogeneous response of p53 to stress
Key Points The tumour suppressor p53 is a master sensor of stress and integrates incoming signals to prevent malignant progression by inducing cellular responses such as apoptosis and senescence. The response to p53 activation is heterogeneous and depends on the nature and intensity of the activatin...
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Published in | Nature reviews. Molecular cell biology Vol. 9; no. 9; pp. 702 - 712 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.09.2008
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Abstract | Key Points
The tumour suppressor p53 is a master sensor of stress and integrates incoming signals to prevent malignant progression by inducing cellular responses such as apoptosis and senescence.
The response to p53 activation is heterogeneous and depends on the nature and intensity of the activating stress and on the cell or tissue type in which the stress is encountered.
Different stimuli induce p53 with different kinetics, which is reflected in the diversity of responses to p53.
Variation is coordinated by post-translational modifications of p53 and the availability of cofactors that together determine the appropriate cellular fate.
These variables dictate the level, subcellular localization and activities of p53, whether its actions are dependent or independent of transcription, and the array of genes the expression of which are altered.
Several new interacting partners of p53 have been identified, and we must now begin to understand how these partners affect p53 activity in tissue- and stress-specific contexts.
The tumour suppressor p53 integrates incoming stress signals to prevent malignant progression by inducing cell responses such as apoptosis and senescence. The specific response, coordinated by p53 post-translational modifications and the availability of p53 cofactors, determines the appropriate cellular fate.
The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation. |
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AbstractList | Key Points
The tumour suppressor p53 is a master sensor of stress and integrates incoming signals to prevent malignant progression by inducing cellular responses such as apoptosis and senescence.
The response to p53 activation is heterogeneous and depends on the nature and intensity of the activating stress and on the cell or tissue type in which the stress is encountered.
Different stimuli induce p53 with different kinetics, which is reflected in the diversity of responses to p53.
Variation is coordinated by post-translational modifications of p53 and the availability of cofactors that together determine the appropriate cellular fate.
These variables dictate the level, subcellular localization and activities of p53, whether its actions are dependent or independent of transcription, and the array of genes the expression of which are altered.
Several new interacting partners of p53 have been identified, and we must now begin to understand how these partners affect p53 activity in tissue- and stress-specific contexts.
The tumour suppressor p53 integrates incoming stress signals to prevent malignant progression by inducing cell responses such as apoptosis and senescence. The specific response, coordinated by p53 post-translational modifications and the availability of p53 cofactors, determines the appropriate cellular fate.
The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation. The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation. |
Audience | Academic |
Author | Murray-Zmijewski, Fiona Lu, Xin Slee, Elizabeth A |
Author_xml | – sequence: 1 givenname: Xin surname: Lu fullname: Lu, Xin organization: Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building – sequence: 2 givenname: Fiona surname: Murray-Zmijewski fullname: Murray-Zmijewski, Fiona organization: Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building – sequence: 3 givenname: Elizabeth A surname: Slee fullname: Slee, Elizabeth A organization: Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18719709$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.cell.2006.05.034 10.1038/sj.onc.1205842 10.1016/S1097-2765(03)00050-9 10.1038/378203a0 10.1016/S1097-2765(04)00157-1 10.1038/ng1070 10.1038/nrc2012 10.1016/j.molcel.2006.01.020 10.1038/sj.onc.1201369 10.1038/sj.emboj.7601560 10.1016/j.tcb.2007.04.004 10.1016/j.molcel.2006.11.026 10.1172/JCI28833 10.1016/j.molcel.2007.05.026 10.1016/j.cell.2005.07.034 10.1128/MCB.22.1.78-93.2002 10.1016/j.molcel.2007.11.036 10.1038/sj.cdd.4401912 10.1101/gad.1567107 10.1038/378206a0 10.1126/science.1092734 10.1126/science.1090072 10.1038/nsmb1306 10.1042/BC20050058 10.1128/MCB.23.20.7083-7095.2003 10.1016/S1097-2765(01)00283-0 10.1126/science.1126391 10.1016/j.cell.2004.06.016 10.1038/ncb715 10.1128/MCB.24.15.6728-6741.2004 10.1093/emboj/18.6.1660 10.1038/sj.cdd.4401562 10.1073/pnas.1432104100 10.1128/MCB.14.9.6264 10.1016/j.molcel.2007.02.007 10.1038/416560a 10.1038/nature06092 10.1101/gad.827700 10.1038/nature737 10.1016/S1097-2765(01)00367-7 10.1016/j.molcel.2005.03.027 10.1073/pnas.0701497104 10.1016/0092-8674(82)90356-7 10.1093/nar/gkl878 10.1038/nature05077 10.1038/nature05287 10.1038/sj.onc.1209490 10.1038/sj.emboj.7601292 10.1073/pnas.94.26.14707 10.1101/gad.10.19.2438 10.1016/S1097-2765(00)80338-X 10.1016/S1097-2765(01)00277-5 10.1080/09553000600949624 10.1038/sj.onc.1203366 10.1016/j.molcel.2006.11.021 10.1016/j.cell.2007.06.013 10.1126/science.1126863 10.1093/emboj/19.22.6185 10.1016/S0092-8674(03)00193-4 10.1016/0092-8674(93)90496-D 10.1128/MCB.00999-06 10.1038/ncb1562 10.1128/MCB.20.22.8458-8467.2000 10.1016/j.drup.2003.10.004 10.1016/j.jmb.2005.03.014 10.1038/sj.emboj.7601469 10.1083/jcb.200512059 10.1016/j.ccr.2007.09.007 10.1038/278261a0 10.1038/35042675 10.1038/nature05993 10.1038/ncb1123 10.1038/nature01850 10.1074/jbc.M610793200 10.1016/0092-8674(94)90071-X 10.1038/sj.onc.1209924 10.1093/emboj/16.13.4117 10.1038/ncb1730 10.1016/0092-8674(79)90293-9 10.1016/j.cell.2007.08.001 10.1016/S0092-8674(02)01255-2 10.1016/j.cell.2006.09.031 10.1093/emboj/cdg579 10.1002/j.1460-2075.1996.tb00418.x 10.1038/sj.cdd.4402196 10.1038/sj.thj.6200260 10.1128/MCB.16.9.4952 10.1158/0008-5472.CAN-05-1084 10.1016/S1535-6108(03)00244-7 10.1016/0042-6822(85)90421-0 10.1073/pnas.0503068102 10.1038/ng714 10.1016/S0092-8674(00)00073-8 10.1038/nature01116 10.1038/nature02514 10.1038/nature01120 10.1038/ncb1170 10.1073/pnas.76.5.2420 10.1038/sj.onc.1203717 10.1038/ncb714 10.1016/j.cell.2006.05.036 10.1038/ncb1638 10.1126/science.1091362 10.1128/MCB.25.13.5389-5395.2005 10.1038/nature02501 |
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References | Lane, D. P., Crawford, L. V. (b1) 1979; 278 Marchenko, N. D., Wolff, S., Erster, S., Becker, K., Moll, U. M. (b69) 2007; 26 Hu, W., Feng, Z., Teresky, A. K., Levine, A. J. (b9) 2007; 450 Demonacos, C., Krstic-Demonacos, M., La Thangue, N. B. (b102) 2001; 8 Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., Evan, G. I. (b107) 2006; 443 Parant, J. (b37) 2001; 29 Takagi, M., Absalon, M. J., McLure, K. G., Kastan, M. B. (b29) 2005; 123 Ludwig, R. L., Bates, S., Vousden, K. H. (b97) 1996; 16 Graeber, T. G. (b23) 1994; 14 Fu, L., Benchimol, S. (b32) 1997; 16 Uldrijan, S., Pannekoek, W. J., Vousden, K. H. (b38) 2007; 26 Komarova, E. A., Christov, K., Faerman, A. I., Gudkov, A. V. (b17) 2000; 19 Fei, P., Bernhard, E. J., El-Deiry, W. S. (b18) 2002; 62 Toledo, F., Wahl, G. M. (b27) 2006; 6 Andrews, P., He, Y. J., Xiong, Y. (b66) 2006; 25 Taira, N., Nihira, K., Yamaguchi, T., Miki, Y., Yoshida, K. (b80) 2007; 25 Takaoka, A. (b28) 2003; 424 Matoba, S. (b12) 2006; 312 Lu, X., Lane, D. P. (b22) 1993; 75 Dornan, D. (b44) 2004; 429 Rowan, S. (b99) 1996; 15 Alvarez, S. (b26) 2006; 82 Shikama, N. (b100) 1999; 4 Li, M., Brooks, C. L., Kon, N., Gu, W. (b42) 2004; 13 Feng, L., Lin, T., Uranishi, H., Gu, W., Xu, Y. (b47) 2005; 25 Teodoro, J. G., Parker, A. E., Zhu, X., Green, M. R. (b14) 2006; 313 Wang, Y. V. (b64) 2007; 104 Budhram-Mahadeo, V. S. (b90) 2006; 34 Huang, J. (b49) 2006; 444 Sarnow, P., Ho, Y. S., Williams, J., Levine, A. J. (b59) 1982; 28 Leng, R. P. (b43) 2003; 112 Weinberg, R. L., Veprintsev, D. B., Bycroft, M., Fersht, A. R. (b77) 2005; 348 Bergamaschi, D. (b87) 2003; 33 Stommel, J. M. (b56) 1999; 18 Hofmann, T. G. (b78) 2002; 4 Crighton, D. (b6) 2006; 126 Amaravadi, R. K. (b7) 2007; 117 Villunger, A. (b20) 2003; 302 Di Giovanni, S. (b85) 2006; 25 Montes de Oca Luna, R., Wagner, D. S., Lozano, G. (b36) 1995; 378 Tasdemir, E. (b70) 2008; 10 Leu, J. I., George, D. L. (b75) 2007; 21 O'Brate, A., Giannakakou, P. (b53) 2003; 6 Zantema, A. (b60) 1985; 142 Erster, S., Mihara, M., Kim, R. H., Petrenko, O., Moll, U. M. (b24) 2004; 24 Demonacos, C. (b101) 2004; 6 Jones, R. G. (b11) 2005; 18 Galban, S. (b30) 2003; 23 D'Orazi, G. (b79) 2002; 4 Cummins, J. M. (b41) 2004; 428 Laine, A., Ronai, Z. (b68) 2007; 26 MacCallum, D. E. (b16) 1996; 13 Li, M. (b40) 2002; 416 Rodriguez, M. S., Desterro, J. M., Lain, S., Lane, D. P., Hay, R. T. (b51) 2000; 20 Mazan-Mamczarz, K. (b31) 2003; 100 Espinosa, J. M., Emerson, B. M. (b106) 2001; 8 Jeffers, J. R. (b21) 2003; 4 Krummel, K. A., Lee, C. J., Toledo, F., Wahl, G. M. (b48) 2005; 102 Fogal, V. (b92) 2000; 19 Flores, E. R. (b88) 2002; 416 Huang, J. (b52) 2007; 449 Woods, Y. L., Lane, D. P. (b15) 2003; 4 Le Cam, L. (b54) 2006; 127 Li, M. (b63) 2003; 302 Vogelstein, B., Lane, D., Levine, A. J. (b4) 2000; 408 Knights, C. D. (b84) 2006; 173 Kanai, M. (b55) 2007; 9 Chen, X., Ko, L. J., Jayaraman, L., Prives, C. (b76) 1996; 10 Olsson, A., Manzl, C., Strasser, A., Villunger, A. (b46) 2007; 14 Yang, W. (b45) 2007; 282 DeLeo, A. B. (b3) 1979; 76 Zheng, H. (b94) 2002; 419 Chipuk, J. E. (b73) 2004; 303 Das, S. (b89) 2007; 130 Crook, T., Marston, N. J., Sara, E. A., Vousden, K. H. (b98) 1994; 79 Rubbi, C. P., Milner, J. (b5) 2003; 22 Bouvard, V. (b19) 2000; 19 Bensaad, K., Vousden, K. H. (b13) 2007; 17 Jones, S. N., Roe, A. E., Donehower, L. A., Bradley, A. (b35) 1995; 378 Xirodimas, D. P., Saville, M. K., Bourdon, J. C., Hay, R. T., Lane, D. P. (b50) 2004; 118 Kitagawa, M., Lee, S. H., McCormick, F. (b103) 2008; 29 Leu, J. I., Dumont, P., Hafey, M., Murphy, M. E., George, D. L. (b72) 2004; 6 Zhao, R. (b25) 2000; 14 Elmore, L. W. (b61) 1997; 94 Linzer, D. I., Levine, A. J. (b2) 1979; 17 Nikolaev, A. Y., Li, M., Puskas, N., Qin, J., Gu, W. (b67) 2003; 112 Samuels-Lev, Y. (b86) 2001; 8 Bensaad, K. (b10) 2006; 126 Mihara, M. (b71) 2003; 11 Hsieh, J. K. (b58) 2002; 22 Brooks, C. L., Gu, W. (b33) 2006; 21 Oda, K. (b81) 2000; 102 Itahana, K. (b39) 2007; 12 Fogal, V. (b57) 2005; 12 Donner, A. J., Szostek, S., Hoover, J. M., Espinosa, J. M. (b105) 2007; 27 Toledo, F. (b96) 2007; 27 Takada, S., Kaneniwa, N., Tsuchida, N., Koike, K. (b62) 1997; 15 Mantovani, F. (b95) 2007; 14 Roger, L., Gadea, G., Roux., P. (b8) 2006; 98 Tang, Y., Luo, J., Zhang, W., Gu, W. (b83) 2006; 24 Tanaka, T., Ohkubo, S., Tatsuno, I., Prives, C. (b104) 2007; 130 Budram-Mahadeo, V., Morris, P. J., Latchman, D. S. (b91) 2002; 21 Talos, F., Petrenko, O., Mena, P., Moll, U. M. (b74) 2005; 65 Zacchi, P. (b93) 2002; 419 Marine, J. C. (b34) 2006; 13 Carter, S., Bischof, O., Dejean, A., Vousden, K. H. (b65) 2007; 9 Sykes, S. M. 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References_xml | – volume: 126 start-page: 121 year: 2006 end-page: 134 ident: b6 publication-title: Cell contributor: fullname: Crighton, D. – volume: 117 start-page: 326 year: 2007 end-page: 336 ident: b7 publication-title: J. Clin. Invest. contributor: fullname: Amaravadi, R. K. – volume: 408 start-page: 307 year: 2000 end-page: 310 ident: b4 publication-title: Nature contributor: fullname: Levine, A. J. – volume: 302 start-page: 1036 year: 2003 end-page: 1038 ident: b20 publication-title: Science contributor: fullname: Villunger, A. – volume: 25 start-page: 5389 year: 2005 end-page: 5395 ident: b47 publication-title: Mol. Cell. Biol. contributor: fullname: Xu, Y. – volume: 449 start-page: 105 year: 2007 end-page: 108 ident: b52 publication-title: Nature contributor: fullname: Huang, J. – volume: 173 start-page: 533 year: 2006 end-page: 544 ident: b84 publication-title: J. Cell Biol. contributor: fullname: Knights, C. D. – volume: 21 start-page: 6123 year: 2002 end-page: 6131 ident: b91 publication-title: Oncogene contributor: fullname: Latchman, D. S. – volume: 17 start-page: 43 year: 1979 end-page: 52 ident: b2 publication-title: Cell contributor: fullname: Levine, A. J. – volume: 11 start-page: 577 year: 2003 end-page: 590 ident: b71 publication-title: Mol. Cell contributor: fullname: Mihara, M. – volume: 10 start-page: 2438 year: 1996 end-page: 2451 ident: b76 publication-title: Genes Dev. contributor: fullname: Prives, C. – volume: 24 start-page: 827 year: 2006 end-page: 839 ident: b83 publication-title: Mol. Cell contributor: fullname: Gu, W. – volume: 21 start-page: 307 year: 2006 end-page: 315 ident: b33 publication-title: Mol. Cell contributor: fullname: Gu, W. – volume: 6 start-page: 443 year: 2004 end-page: 450 ident: b72 publication-title: Nature Cell Biol. contributor: fullname: George, D. L. – volume: 33 start-page: 162 year: 2003 end-page: 167 ident: b87 publication-title: Nature Genet. contributor: fullname: Bergamaschi, D. – volume: 123 start-page: 49 year: 2005 end-page: 63 ident: b29 publication-title: Cell contributor: fullname: Kastan, M. B. – volume: 443 start-page: 214 year: 2006 end-page: 217 ident: b107 publication-title: Nature contributor: fullname: Evan, G. I. – volume: 419 start-page: 853 year: 2002 end-page: 857 ident: b93 publication-title: Nature contributor: fullname: Zacchi, P. – volume: 8 start-page: 57 year: 2001 end-page: 69 ident: b106 publication-title: Mol. Cell contributor: fullname: Emerson, B. M. – volume: 82 start-page: 761 year: 2006 end-page: 770 ident: b26 publication-title: Int. J. Radiat. Biol. contributor: fullname: Alvarez, S. – volume: 22 start-page: 6068 year: 2003 end-page: 6077 ident: b5 publication-title: EMBO J. contributor: fullname: Milner, J. – volume: 142 start-page: 44 year: 1985 end-page: 58 ident: b60 publication-title: Virology contributor: fullname: Zantema, A. – volume: 102 start-page: 849 year: 2000 end-page: 862 ident: b81 publication-title: Cell contributor: fullname: Oda, K. – volume: 4 start-page: 321 year: 2003 end-page: 328 ident: b21 publication-title: Cancer Cell contributor: fullname: Jeffers, J. R. – volume: 303 start-page: 1010 year: 2004 end-page: 1014 ident: b73 publication-title: Science contributor: fullname: Chipuk, J. E. – volume: 10 start-page: 676 year: 2008 end-page: 687 ident: b70 publication-title: Nature Cell Biol. contributor: fullname: Tasdemir, E. – volume: 9 start-page: 1175 year: 2007 end-page: 1183 ident: b55 publication-title: Nature Cell Biol. contributor: fullname: Kanai, M. – volume: 15 start-page: 827 year: 1996 end-page: 838 ident: b99 publication-title: EMBO J. contributor: fullname: Rowan, S. – volume: 130 start-page: 624 year: 2007 end-page: 637 ident: b89 publication-title: Cell contributor: fullname: Das, S. – volume: 21 start-page: 3095 year: 2007 end-page: 3109 ident: b75 publication-title: Genes Dev. contributor: fullname: George, D. L. – volume: 424 start-page: 516 year: 2003 end-page: 523 ident: b28 publication-title: Nature contributor: fullname: Takaoka, A. – volume: 444 start-page: 629 year: 2006 end-page: 632 ident: b49 publication-title: Nature contributor: fullname: Huang, J. – volume: 15 start-page: 1895 year: 1997 end-page: 1901 ident: b62 publication-title: Oncogene contributor: fullname: Koike, K. – volume: 13 start-page: 2575 year: 1996 end-page: 2587 ident: b16 publication-title: Oncogene contributor: fullname: MacCallum, D. E. – volume: 29 start-page: 217 year: 2008 end-page: 231 ident: b103 publication-title: Mol. Cell contributor: fullname: McCormick, F. – volume: 13 start-page: 927 year: 2006 end-page: 934 ident: b34 publication-title: Cell Death Differ. contributor: fullname: Marine, J. C. – volume: 94 start-page: 14707 year: 1997 end-page: 14712 ident: b61 publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Elmore, L. W. – volume: 282 start-page: 3273 year: 2007 end-page: 3281 ident: b45 publication-title: J. Biol. Chem. contributor: fullname: Yang, W. – volume: 25 start-page: 725 year: 2007 end-page: 738 ident: b80 publication-title: Mol. Cell contributor: fullname: Yoshida, K. – volume: 12 start-page: 355 year: 2007 end-page: 366 ident: b39 publication-title: Cancer Cell contributor: fullname: Itahana, K. – volume: 112 start-page: 29 year: 2003 end-page: 40 ident: b67 publication-title: Cell contributor: fullname: Gu, W. – volume: 378 start-page: 203 year: 1995 end-page: 206 ident: b36 publication-title: Nature contributor: fullname: Lozano, G. – volume: 8 start-page: 781 year: 2001 end-page: 794 ident: b86 publication-title: Mol. Cell contributor: fullname: Samuels-Lev, Y. – volume: 130 start-page: 638 year: 2007 end-page: 650 ident: b104 publication-title: Cell contributor: fullname: Prives, C. – volume: 4 start-page: 1 year: 2002 end-page: 10 ident: b78 publication-title: Nature Cell Biol. contributor: fullname: Hofmann, T. G. – volume: 4 start-page: 11 year: 2002 end-page: 19 ident: b79 publication-title: Nature Cell Biol. contributor: fullname: D'Orazi, G. – volume: 118 start-page: 83 year: 2004 end-page: 97 ident: b50 publication-title: Cell contributor: fullname: Lane, D. P. – volume: 25 start-page: 4084 year: 2006 end-page: 4096 ident: b85 publication-title: EMBO J. contributor: fullname: Di Giovanni, S. – volume: 76 start-page: 2420 year: 1979 end-page: 2424 ident: b3 publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: DeLeo, A. B. – volume: 18 start-page: 283 year: 2005 end-page: 293 ident: b11 publication-title: Mol. Cell contributor: fullname: Jones, R. G. – volume: 19 start-page: 649 year: 2000 end-page: 660 ident: b19 publication-title: Oncogene contributor: fullname: Bouvard, V. – volume: 18 start-page: 1660 year: 1999 end-page: 1672 ident: b56 publication-title: EMBO J. contributor: fullname: Stommel, J. M. – volume: 14 start-page: 6264 year: 1994 end-page: 6277 ident: b23 publication-title: Mol. Cell. Biol. contributor: fullname: Graeber, T. G. – volume: 79 start-page: 817 year: 1994 end-page: 827 ident: b98 publication-title: Cell contributor: fullname: Vousden, K. H. – volume: 22 start-page: 78 year: 2002 end-page: 93 ident: b58 publication-title: Mol. Cell. Biol. contributor: fullname: Hsieh, J. K. – volume: 278 start-page: 261 year: 1979 end-page: 263 ident: b1 publication-title: Nature contributor: fullname: Crawford, L. V. – volume: 9 start-page: 428 year: 2007 end-page: 435 ident: b65 publication-title: Nature Cell Biol. contributor: fullname: Vousden, K. H. – volume: 6 start-page: 968 year: 2004 end-page: 976 ident: b101 publication-title: Nature Cell Biol. contributor: fullname: Demonacos, C. – volume: 100 start-page: 8354 year: 2003 end-page: 8359 ident: b31 publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Mazan-Mamczarz, K. – volume: 428 year: 2004 ident: b41 publication-title: Nature contributor: fullname: Cummins, J. M. – volume: 27 start-page: 1425 year: 2007 end-page: 1432 ident: b96 publication-title: Mol. Cell. Biol. contributor: fullname: Toledo, F. – volume: 28 start-page: 387 year: 1982 end-page: 394 ident: b59 publication-title: Cell contributor: fullname: Levine, A. J. – volume: 126 start-page: 107 year: 2006 end-page: 120 ident: b10 publication-title: Cell contributor: fullname: Bensaad, K. – volume: 429 start-page: 86 year: 2004 end-page: 92 ident: b44 publication-title: Nature contributor: fullname: Dornan, D. – volume: 416 start-page: 560 year: 2002 end-page: 564 ident: b88 publication-title: Nature contributor: fullname: Flores, E. R. – volume: 378 start-page: 206 year: 1995 end-page: 208 ident: b35 publication-title: Nature contributor: fullname: Bradley, A. – volume: 20 start-page: 8458 year: 2000 end-page: 8467 ident: b51 publication-title: Mol. Cell. Biol. contributor: fullname: Hay, R. T. – volume: 29 start-page: 92 year: 2001 end-page: 95 ident: b37 publication-title: Nature Genet. contributor: fullname: Parant, J. – volume: 419 start-page: 849 year: 2002 end-page: 853 ident: b94 publication-title: Nature contributor: fullname: Zheng, H. – volume: 14 start-page: 912 year: 2007 end-page: 920 ident: b95 publication-title: Nature Struct. Mol. Biol. contributor: fullname: Mantovani, F. – volume: 416 start-page: 648 year: 2002 end-page: 653 ident: b40 publication-title: Nature contributor: fullname: Li, M. – volume: 24 start-page: 6728 year: 2004 end-page: 6741 ident: b24 publication-title: Mol. Cell. Biol. contributor: fullname: Moll, U. M. – volume: 34 start-page: 6640 year: 2006 end-page: 6652 ident: b90 publication-title: Nucleic Acids Res. contributor: fullname: Budhram-Mahadeo, V. S. – volume: 14 start-page: 1561 year: 2007 end-page: 1575 ident: b46 publication-title: Cell Death Differ. contributor: fullname: Villunger, A. – volume: 26 start-page: 923 year: 2007 end-page: 934 ident: b69 publication-title: EMBO J. contributor: fullname: Moll, U. M. – volume: 348 start-page: 589 year: 2005 end-page: 596 ident: b77 publication-title: J. Mol. Biol. contributor: fullname: Fersht, A. R. – volume: 98 start-page: 141 year: 2006 end-page: 152 ident: b8 publication-title: Biol. Cell contributor: fullname: Roux., P. – volume: 313 start-page: 968 year: 2006 end-page: 971 ident: b14 publication-title: Science contributor: fullname: Green, M. R. – volume: 13 start-page: 879 year: 2004 end-page: 886 ident: b42 publication-title: Mol. Cell contributor: fullname: Gu, W. – volume: 6 start-page: 909 year: 2006 end-page: 923 ident: b27 publication-title: Nature Rev. Cancer contributor: fullname: Wahl, G. M. – volume: 112 start-page: 779 year: 2003 end-page: 791 ident: b43 publication-title: Cell contributor: fullname: Leng, R. P. – volume: 75 start-page: 765 year: 1993 end-page: 778 ident: b22 publication-title: Cell contributor: fullname: Lane, D. P. – volume: 104 start-page: 12365 year: 2007 end-page: 12370 ident: b64 publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Wang, Y. V. – volume: 16 start-page: 4952 year: 1996 end-page: 4960 ident: b97 publication-title: Mol. Cell. Biol. contributor: fullname: Vousden, K. H. – volume: 102 start-page: 10188 year: 2005 end-page: 10193 ident: b48 publication-title: Proc. Natl Acad. Sci. USA contributor: fullname: Wahl, G. M. – volume: 24 start-page: 841 year: 2006 end-page: 851 ident: b82 publication-title: Mol. Cell contributor: fullname: Sykes, S. M. – volume: 26 start-page: 102 year: 2007 end-page: 112 ident: b38 publication-title: EMBO J. contributor: fullname: Vousden, K. H. – volume: 14 start-page: 981 year: 2000 end-page: 993 ident: b25 publication-title: Genes Dev. contributor: fullname: Zhao, R. – volume: 19 start-page: 6185 year: 2000 end-page: 6195 ident: b92 publication-title: EMBO J. contributor: fullname: Fogal, V. – volume: 27 start-page: 121 year: 2007 end-page: 133 ident: b105 publication-title: Mol. Cell contributor: fullname: Espinosa, J. M. – volume: 17 start-page: 286 year: 2007 end-page: 291 ident: b13 publication-title: Trends Cell Biol. contributor: fullname: Vousden, K. H. – volume: 26 start-page: 1477 year: 2007 end-page: 1483 ident: b68 publication-title: Oncogene contributor: fullname: Ronai, Z. – volume: 4 start-page: 233 year: 2003 end-page: 247 ident: b15 publication-title: Hematol. J. contributor: fullname: Lane, D. P. – volume: 312 start-page: 1650 year: 2006 end-page: 1653 ident: b12 publication-title: Science contributor: fullname: Matoba, S. – volume: 25 start-page: 4534 year: 2006 end-page: 4548 ident: b66 publication-title: Oncogene contributor: fullname: Xiong, Y. – volume: 19 start-page: 3791 year: 2000 end-page: 3798 ident: b17 publication-title: Oncogene contributor: fullname: Gudkov, A. V. – volume: 12 start-page: 369 year: 2005 end-page: 376 ident: b57 publication-title: Cell Death Differ. contributor: fullname: Fogal, V. – volume: 6 start-page: 313 year: 2003 end-page: 322 ident: b53 publication-title: Drug Resist. Update contributor: fullname: Giannakakou, P. – volume: 23 start-page: 7083 year: 2003 end-page: 7095 ident: b30 publication-title: Mol. Cell. Biol. contributor: fullname: Galban, S. – volume: 4 start-page: 365 year: 1999 end-page: 376 ident: b100 publication-title: Mol. Cell contributor: fullname: Shikama, N. – volume: 16 start-page: 4117 year: 1997 end-page: 4125 ident: b32 publication-title: EMBO J. contributor: fullname: Benchimol, S. – volume: 62 start-page: 7316 year: 2002 end-page: 7327 ident: b18 publication-title: Cancer Res. contributor: fullname: El-Deiry, W. S. – volume: 8 start-page: 71 year: 2001 end-page: 84 ident: b102 publication-title: Mol. Cell contributor: fullname: La Thangue, N. B. – volume: 450 start-page: 721 year: 2007 end-page: 724 ident: b9 publication-title: Nature contributor: fullname: Levine, A. J. – volume: 127 start-page: 775 year: 2006 end-page: 788 ident: b54 publication-title: Cell contributor: fullname: Le Cam, L. – volume: 65 start-page: 9971 year: 2005 end-page: 9981 ident: b74 publication-title: Cancer Res. contributor: fullname: Moll, U. M. – volume: 302 start-page: 1972 year: 2003 end-page: 1975 ident: b63 publication-title: Science contributor: fullname: Li, M. – volume: 126 start-page: 121 year: 2006 end-page: 134 ident: CR6 article-title: DRAM, a p53-induced modulator of autophagy, is critical for apoptosis publication-title: Cell doi: 10.1016/j.cell.2006.05.034 contributor: fullname: Crighton – volume: 21 start-page: 6123 year: 2002 end-page: 6131 ident: CR91 article-title: The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1) publication-title: Oncogene doi: 10.1038/sj.onc.1205842 contributor: fullname: Latchman – volume: 11 start-page: 577 year: 2003 end-page: 590 ident: CR71 article-title: p53 has a direct apoptogenic role at the mitochondria publication-title: Mol. Cell doi: 10.1016/S1097-2765(03)00050-9 contributor: fullname: Mihara – volume: 378 start-page: 203 year: 1995 end-page: 206 ident: CR36 article-title: Rescue of early embryonic lethality in Mdm2-deficient mice by deletion of p53 publication-title: Nature doi: 10.1038/378203a0 contributor: fullname: Lozano – volume: 13 start-page: 879 year: 2004 end-page: 886 ident: CR42 article-title: A dynamic role of HAUSP in the p53–Mdm2 pathway publication-title: Mol. Cell doi: 10.1016/S1097-2765(04)00157-1 contributor: fullname: Gu – volume: 33 start-page: 162 year: 2003 end-page: 167 ident: CR87 article-title: iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human publication-title: Nature Genet. doi: 10.1038/ng1070 contributor: fullname: Bergamaschi – volume: 6 start-page: 909 year: 2006 end-page: 923 ident: CR27 article-title: Regulating the p53 pathway: hypotheses, veritas publication-title: Nature Rev. Cancer doi: 10.1038/nrc2012 contributor: fullname: Wahl – volume: 21 start-page: 307 year: 2006 end-page: 315 ident: CR33 article-title: p53 ubiquitination: Mdm2 and beyond publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.01.020 contributor: fullname: Gu – volume: 15 start-page: 1895 year: 1997 end-page: 1901 ident: CR62 article-title: Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells publication-title: Oncogene doi: 10.1038/sj.onc.1201369 contributor: fullname: Koike – volume: 26 start-page: 923 year: 2007 end-page: 934 ident: CR69 article-title: Monoubiquitylation promotes mitochondrial p53 translocation publication-title: EMBO J. doi: 10.1038/sj.emboj.7601560 contributor: fullname: Moll – volume: 17 start-page: 286 year: 2007 end-page: 291 ident: CR13 article-title: p53: new roles in metabolism publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2007.04.004 contributor: fullname: Vousden – volume: 24 start-page: 841 year: 2006 end-page: 851 ident: CR82 article-title: Acetylation of the p53 DNA-binding domain regulates apoptosis induction publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.11.026 contributor: fullname: Sykes – volume: 117 start-page: 326 year: 2007 end-page: 336 ident: CR7 article-title: Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma publication-title: J. Clin. Invest. doi: 10.1172/JCI28833 contributor: fullname: Amaravadi – volume: 27 start-page: 121 year: 2007 end-page: 133 ident: CR105 article-title: CDK8 is a stimulus-specific positive coregulator of p53 target genes publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.05.026 contributor: fullname: Espinosa – volume: 123 start-page: 49 year: 2005 end-page: 63 ident: CR29 article-title: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin publication-title: Cell doi: 10.1016/j.cell.2005.07.034 contributor: fullname: Kastan – volume: 22 start-page: 78 year: 2002 end-page: 93 ident: CR58 article-title: Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.1.78-93.2002 contributor: fullname: Hsieh – volume: 29 start-page: 217 year: 2008 end-page: 231 ident: CR103 article-title: Skp2 suppresses p53-dependent apoptosis by inhibiting p300 publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.11.036 contributor: fullname: McCormick – volume: 13 start-page: 927 year: 2006 end-page: 934 ident: CR34 article-title: Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401912 contributor: fullname: Marine – volume: 21 start-page: 3095 year: 2007 end-page: 3109 ident: CR75 article-title: Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria publication-title: Genes Dev. doi: 10.1101/gad.1567107 contributor: fullname: George – volume: 378 start-page: 206 year: 1995 end-page: 208 ident: CR35 article-title: Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 publication-title: Nature doi: 10.1038/378206a0 contributor: fullname: Bradley – volume: 303 start-page: 1010 year: 2004 end-page: 1014 ident: CR73 article-title: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis publication-title: Science doi: 10.1126/science.1092734 contributor: fullname: Chipuk – volume: 302 start-page: 1036 year: 2003 end-page: 1038 ident: CR20 article-title: p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa publication-title: Science doi: 10.1126/science.1090072 contributor: fullname: Villunger – volume: 14 start-page: 912 year: 2007 end-page: 920 ident: CR95 article-title: The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP publication-title: Nature Struct. Mol. Biol. doi: 10.1038/nsmb1306 contributor: fullname: Mantovani – volume: 98 start-page: 141 year: 2006 end-page: 152 ident: CR8 article-title: Control of cell migration: a tumour suppressor function for p53? publication-title: Biol. Cell doi: 10.1042/BC20050058 contributor: fullname: Roux. – volume: 23 start-page: 7083 year: 2003 end-page: 7095 ident: CR30 article-title: Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.20.7083-7095.2003 contributor: fullname: Galban – volume: 8 start-page: 57 year: 2001 end-page: 69 ident: CR106 article-title: Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00283-0 contributor: fullname: Emerson – volume: 313 start-page: 968 year: 2006 end-page: 971 ident: CR14 article-title: p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase publication-title: Science doi: 10.1126/science.1126391 contributor: fullname: Green – volume: 118 start-page: 83 year: 2004 end-page: 97 ident: CR50 article-title: MDM2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity publication-title: Cell doi: 10.1016/j.cell.2004.06.016 contributor: fullname: Lane – volume: 4 start-page: 1 year: 2002 end-page: 10 ident: CR78 article-title: Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 publication-title: Nature Cell Biol. doi: 10.1038/ncb715 contributor: fullname: Hofmann – volume: 24 start-page: 6728 year: 2004 end-page: 6741 ident: CR24 article-title: mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.15.6728-6741.2004 contributor: fullname: Moll – volume: 18 start-page: 1660 year: 1999 end-page: 1672 ident: CR56 article-title: A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking publication-title: EMBO J. doi: 10.1093/emboj/18.6.1660 contributor: fullname: Stommel – volume: 12 start-page: 369 year: 2005 end-page: 376 ident: CR57 article-title: ASPP1 and ASPP2 are new transcriptional targets of E2F publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401562 contributor: fullname: Fogal – volume: 100 start-page: 8354 year: 2003 end-page: 8359 ident: CR31 article-title: RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1432104100 contributor: fullname: Mazan-Mamczarz – volume: 14 start-page: 6264 year: 1994 end-page: 6277 ident: CR23 article-title: Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.14.9.6264 contributor: fullname: Graeber – volume: 25 start-page: 725 year: 2007 end-page: 738 ident: CR80 article-title: DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.02.007 contributor: fullname: Yoshida – volume: 416 start-page: 560 year: 2002 end-page: 564 ident: CR88 article-title: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage publication-title: Nature doi: 10.1038/416560a contributor: fullname: Flores – volume: 449 start-page: 105 year: 2007 end-page: 108 ident: CR52 article-title: p53 is regulated by the lysine demethylase LSD1 publication-title: Nature doi: 10.1038/nature06092 contributor: fullname: Huang – volume: 14 start-page: 981 year: 2000 end-page: 993 ident: CR25 article-title: Analysis of p53-regulated gene expression patterns using oligonucleotide arrays publication-title: Genes Dev. doi: 10.1101/gad.827700 contributor: fullname: Zhao – volume: 416 start-page: 648 year: 2002 end-page: 653 ident: CR40 article-title: Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization publication-title: Nature doi: 10.1038/nature737 contributor: fullname: Li – volume: 8 start-page: 781 year: 2001 end-page: 794 ident: CR86 article-title: ASPP proteins specifically stimulate the apoptotic function of p53 publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00367-7 contributor: fullname: Samuels-Lev – volume: 18 start-page: 283 year: 2005 end-page: 293 ident: CR11 article-title: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint publication-title: Mol. Cell doi: 10.1016/j.molcel.2005.03.027 contributor: fullname: Jones – volume: 104 start-page: 12365 year: 2007 end-page: 12370 ident: CR64 article-title: Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0701497104 contributor: fullname: Wang – volume: 28 start-page: 387 year: 1982 end-page: 394 ident: CR59 article-title: Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells publication-title: Cell doi: 10.1016/0092-8674(82)90356-7 contributor: fullname: Levine – volume: 34 start-page: 6640 year: 2006 end-page: 6652 ident: CR90 article-title: Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of expression publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl878 contributor: fullname: Budhram-Mahadeo – volume: 443 start-page: 214 year: 2006 end-page: 217 ident: CR107 article-title: The pathological response to DNA damage does not contribute to p53-mediated tumour suppression publication-title: Nature doi: 10.1038/nature05077 contributor: fullname: Evan – volume: 444 start-page: 629 year: 2006 end-page: 632 ident: CR49 article-title: Repression of p53 activity by Smyd2-mediated methylation publication-title: Nature doi: 10.1038/nature05287 contributor: fullname: Huang – volume: 25 start-page: 4534 year: 2006 end-page: 4548 ident: CR66 article-title: Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function publication-title: Oncogene doi: 10.1038/sj.onc.1209490 contributor: fullname: Xiong – volume: 13 start-page: 2575 year: 1996 end-page: 2587 ident: CR16 article-title: The p53 response to ionising radiation in adult and developing murine tissues publication-title: Oncogene contributor: fullname: MacCallum – volume: 25 start-page: 4084 year: 2006 end-page: 4096 ident: CR85 article-title: The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration publication-title: EMBO J. doi: 10.1038/sj.emboj.7601292 contributor: fullname: Di Giovanni – volume: 94 start-page: 14707 year: 1997 end-page: 14712 ident: CR61 article-title: Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.26.14707 contributor: fullname: Elmore – volume: 10 start-page: 2438 year: 1996 end-page: 2451 ident: CR76 article-title: p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells publication-title: Genes Dev. doi: 10.1101/gad.10.19.2438 contributor: fullname: Prives – volume: 4 start-page: 365 year: 1999 end-page: 376 ident: CR100 article-title: A novel cofactor for p300 that regulates the p53 response publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80338-X contributor: fullname: Shikama – ident: CR41 – volume: 62 start-page: 7316 year: 2002 end-page: 7327 ident: CR18 article-title: Tissue-specific induction of p53 targets publication-title: Cancer Res. contributor: fullname: El-Deiry – volume: 8 start-page: 71 year: 2001 end-page: 84 ident: CR102 article-title: A TPR motif cofactor contributes to p300 activity in the p53 response publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00277-5 contributor: fullname: La Thangue – volume: 82 start-page: 761 year: 2006 end-page: 770 ident: CR26 article-title: A comprehensive study of p53 transcriptional activity in thymus and spleen of γ-irradiated mouse: high sensitivity of genes involved in the two main apoptotic pathways publication-title: Int. J. Radiat. Biol. doi: 10.1080/09553000600949624 contributor: fullname: Alvarez – volume: 19 start-page: 649 year: 2000 end-page: 660 ident: CR19 article-title: Tissue and cell-specific expression of the p53-target genes: , , and / , before and following ionising irradiation in mice publication-title: Oncogene doi: 10.1038/sj.onc.1203366 contributor: fullname: Bouvard – volume: 24 start-page: 827 year: 2006 end-page: 839 ident: CR83 article-title: Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.11.021 contributor: fullname: Gu – volume: 130 start-page: 624 year: 2007 end-page: 637 ident: CR89 article-title: Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation publication-title: Cell doi: 10.1016/j.cell.2007.06.013 contributor: fullname: Das – volume: 312 start-page: 1650 year: 2006 end-page: 1653 ident: CR12 article-title: p53 regulates mitochondrial respiration publication-title: Science doi: 10.1126/science.1126863 contributor: fullname: Matoba – volume: 19 start-page: 6185 year: 2000 end-page: 6195 ident: CR92 article-title: Regulation of p53 activity in nuclear bodies by a specific PML isoform publication-title: EMBO J. doi: 10.1093/emboj/19.22.6185 contributor: fullname: Fogal – volume: 112 start-page: 779 year: 2003 end-page: 791 ident: CR43 article-title: Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation publication-title: Cell doi: 10.1016/S0092-8674(03)00193-4 contributor: fullname: Leng – volume: 75 start-page: 765 year: 1993 end-page: 778 ident: CR22 article-title: Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? publication-title: Cell doi: 10.1016/0092-8674(93)90496-D contributor: fullname: Lane – volume: 27 start-page: 1425 year: 2007 end-page: 1432 ident: CR96 article-title: Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00999-06 contributor: fullname: Toledo – volume: 9 start-page: 428 year: 2007 end-page: 435 ident: CR65 article-title: C-terminal modifications regulate MDM2 dissociation and nuclear export of p53 publication-title: Nature Cell Biol. doi: 10.1038/ncb1562 contributor: fullname: Vousden – volume: 20 start-page: 8458 year: 2000 end-page: 8467 ident: CR51 article-title: Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.22.8458-8467.2000 contributor: fullname: Hay – volume: 6 start-page: 313 year: 2003 end-page: 322 ident: CR53 article-title: The importance of p53 location: nuclear or cytoplasmic zip code? publication-title: Drug Resist. Update doi: 10.1016/j.drup.2003.10.004 contributor: fullname: Giannakakou – volume: 348 start-page: 589 year: 2005 end-page: 596 ident: CR77 article-title: Comparative binding of p53 to its promoter and DNA recognition elements publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2005.03.014 contributor: fullname: Fersht – volume: 26 start-page: 102 year: 2007 end-page: 112 ident: CR38 article-title: An essential function of the extreme C-terminus of MDM2 can be provided by MDMX publication-title: EMBO J. doi: 10.1038/sj.emboj.7601469 contributor: fullname: Vousden – volume: 173 start-page: 533 year: 2006 end-page: 544 ident: CR84 article-title: Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate publication-title: J. Cell Biol. doi: 10.1083/jcb.200512059 contributor: fullname: Knights – volume: 12 start-page: 355 year: 2007 end-page: 366 ident: CR39 article-title: Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.09.007 contributor: fullname: Itahana – volume: 278 start-page: 261 year: 1979 end-page: 263 ident: CR1 article-title: T antigen is bound to a host protein in SV40-transformed cells publication-title: Nature doi: 10.1038/278261a0 contributor: fullname: Crawford – volume: 408 start-page: 307 year: 2000 end-page: 310 ident: CR4 article-title: Surfing the p53 network publication-title: Nature doi: 10.1038/35042675 contributor: fullname: Levine – volume: 450 start-page: 721 year: 2007 end-page: 724 ident: CR9 article-title: p53 regulates maternal reproduction through LIF publication-title: Nature doi: 10.1038/nature05993 contributor: fullname: Levine – volume: 6 start-page: 443 year: 2004 end-page: 450 ident: CR72 article-title: Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex publication-title: Nature Cell Biol. doi: 10.1038/ncb1123 contributor: fullname: George – volume: 424 start-page: 516 year: 2003 end-page: 523 ident: CR28 article-title: Integration of interferon-α /β signalling to p53 responses in tumour suppression and antiviral defence publication-title: Nature doi: 10.1038/nature01850 contributor: fullname: Takaoka – volume: 282 start-page: 3273 year: 2007 end-page: 3281 ident: CR45 article-title: CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M610793200 contributor: fullname: Yang – volume: 79 start-page: 817 year: 1994 end-page: 827 ident: CR98 article-title: Transcriptional activation by p53 correlates with suppression of growth but not transformation publication-title: Cell doi: 10.1016/0092-8674(94)90071-X contributor: fullname: Vousden – volume: 26 start-page: 1477 year: 2007 end-page: 1483 ident: CR68 article-title: Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1 publication-title: Oncogene doi: 10.1038/sj.onc.1209924 contributor: fullname: Ronai – volume: 16 start-page: 4117 year: 1997 end-page: 4125 ident: CR32 article-title: Participation of the human p53 3′ UTR in translational repression and activation following γ-irradiation publication-title: EMBO J. doi: 10.1093/emboj/16.13.4117 contributor: fullname: Benchimol – volume: 10 start-page: 676 year: 2008 end-page: 687 ident: CR70 article-title: Regulation of autophagy by cytoplasmic p53 publication-title: Nature Cell Biol. doi: 10.1038/ncb1730 contributor: fullname: Tasdemir – volume: 17 start-page: 43 year: 1979 end-page: 52 ident: CR2 article-title: Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells publication-title: Cell doi: 10.1016/0092-8674(79)90293-9 contributor: fullname: Levine – volume: 130 start-page: 638 year: 2007 end-page: 650 ident: CR104 article-title: hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes publication-title: Cell doi: 10.1016/j.cell.2007.08.001 contributor: fullname: Prives – volume: 112 start-page: 29 year: 2003 end-page: 40 ident: CR67 article-title: Parc: a cytoplasmic anchor for p53 publication-title: Cell doi: 10.1016/S0092-8674(02)01255-2 contributor: fullname: Gu – volume: 127 start-page: 775 year: 2006 end-page: 788 ident: CR54 article-title: E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation publication-title: Cell doi: 10.1016/j.cell.2006.09.031 contributor: fullname: Le Cam – volume: 22 start-page: 6068 year: 2003 end-page: 6077 ident: CR5 article-title: Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses publication-title: EMBO J. doi: 10.1093/emboj/cdg579 contributor: fullname: Milner – volume: 15 start-page: 827 year: 1996 end-page: 838 ident: CR99 article-title: Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant publication-title: EMBO J. doi: 10.1002/j.1460-2075.1996.tb00418.x contributor: fullname: Rowan – volume: 14 start-page: 1561 year: 2007 end-page: 1575 ident: CR46 article-title: How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4402196 contributor: fullname: Villunger – volume: 4 start-page: 233 year: 2003 end-page: 247 ident: CR15 article-title: Exploiting the p53 pathway for cancer diagnosis and therapy publication-title: Hematol. J. doi: 10.1038/sj.thj.6200260 contributor: fullname: Lane – volume: 16 start-page: 4952 year: 1996 end-page: 4960 ident: CR97 article-title: Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.16.9.4952 contributor: fullname: Vousden – volume: 65 start-page: 9971 year: 2005 end-page: 9981 ident: CR74 article-title: Mitochondrially targeted p53 has tumor suppressor activities publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-1084 contributor: fullname: Moll – volume: 4 start-page: 321 year: 2003 end-page: 328 ident: CR21 article-title: Puma is an essential mediator of p53-dependent and -independent apoptotic pathways publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00244-7 contributor: fullname: Jeffers – volume: 142 start-page: 44 year: 1985 end-page: 58 ident: CR60 article-title: Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies publication-title: Virology doi: 10.1016/0042-6822(85)90421-0 contributor: fullname: Zantema – volume: 102 start-page: 10188 year: 2005 end-page: 10193 ident: CR48 article-title: The C-terminal lysines fine-tune p53 stress responses in a mouse model but are not required for stability control or transactivation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0503068102 contributor: fullname: Wahl – volume: 29 start-page: 92 year: 2001 end-page: 95 ident: CR37 article-title: Rescue of embryonic lethality in -null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 publication-title: Nature Genet. doi: 10.1038/ng714 contributor: fullname: Parant – volume: 102 start-page: 849 year: 2000 end-page: 862 ident: CR81 article-title: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 publication-title: Cell doi: 10.1016/S0092-8674(00)00073-8 contributor: fullname: Oda – volume: 419 start-page: 849 year: 2002 end-page: 853 ident: CR94 article-title: The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response publication-title: Nature doi: 10.1038/nature01116 contributor: fullname: Zheng – volume: 429 start-page: 86 year: 2004 end-page: 92 ident: CR44 article-title: The ubiquitin ligase COP1 is a critical negative regulator of p53 publication-title: Nature doi: 10.1038/nature02514 contributor: fullname: Dornan – volume: 419 start-page: 853 year: 2002 end-page: 857 ident: CR93 article-title: The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults publication-title: Nature doi: 10.1038/nature01120 contributor: fullname: Zacchi – volume: 6 start-page: 968 year: 2004 end-page: 976 ident: CR101 article-title: A new effector pathway links ATM kinase with the DNA damage response publication-title: Nature Cell Biol. doi: 10.1038/ncb1170 contributor: fullname: Demonacos – volume: 76 start-page: 2420 year: 1979 end-page: 2424 ident: CR3 article-title: Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.76.5.2420 contributor: fullname: DeLeo – volume: 19 start-page: 3791 year: 2000 end-page: 3798 ident: CR17 article-title: Different impact of p53 and p21 on the radiation response of mouse tissues publication-title: Oncogene doi: 10.1038/sj.onc.1203717 contributor: fullname: Gudkov – volume: 4 start-page: 11 year: 2002 end-page: 19 ident: CR79 article-title: Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser46 and mediates apoptosis publication-title: Nature Cell Biol. doi: 10.1038/ncb714 contributor: fullname: D'Orazi – volume: 126 start-page: 107 year: 2006 end-page: 120 ident: CR10 article-title: TIGAR, a p53-inducible regulator of glycolysis and apoptosis publication-title: Cell doi: 10.1016/j.cell.2006.05.036 contributor: fullname: Bensaad – volume: 9 start-page: 1175 year: 2007 end-page: 1183 ident: CR55 article-title: Inhibition of Crm1–p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation publication-title: Nature Cell Biol. doi: 10.1038/ncb1638 contributor: fullname: Kanai – volume: 302 start-page: 1972 year: 2003 end-page: 1975 ident: CR63 article-title: Mono- versus polyubiquitination: differential control of p53 fate by Mdm2 publication-title: Science doi: 10.1126/science.1091362 contributor: fullname: Li – volume: 25 start-page: 5389 year: 2005 end-page: 5395 ident: CR47 article-title: Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.13.5389-5395.2005 contributor: fullname: Xu – volume: 104 start-page: 12365 year: 2007 ident: BFnrm2451_CR64 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0701497104 contributor: fullname: YV Wang – volume: 25 start-page: 4084 year: 2006 ident: BFnrm2451_CR85 publication-title: EMBO J. doi: 10.1038/sj.emboj.7601292 contributor: fullname: S Di Giovanni – volume: 33 start-page: 162 year: 2003 ident: BFnrm2451_CR87 publication-title: Nature Genet. doi: 10.1038/ng1070 contributor: fullname: D Bergamaschi – volume: 15 start-page: 827 year: 1996 ident: BFnrm2451_CR99 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1996.tb00418.x contributor: fullname: S Rowan – volume: 348 start-page: 589 year: 2005 ident: BFnrm2451_CR77 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2005.03.014 contributor: fullname: RL Weinberg – volume: 8 start-page: 57 year: 2001 ident: BFnrm2451_CR106 publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00283-0 contributor: fullname: JM Espinosa – volume: 27 start-page: 121 year: 2007 ident: BFnrm2451_CR105 publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.05.026 contributor: fullname: AJ Donner – volume: 6 start-page: 968 year: 2004 ident: BFnrm2451_CR101 publication-title: Nature Cell Biol. doi: 10.1038/ncb1170 contributor: fullname: C Demonacos – volume: 378 start-page: 206 year: 1995 ident: BFnrm2451_CR35 publication-title: Nature doi: 10.1038/378206a0 contributor: fullname: SN Jones – volume: 25 start-page: 4534 year: 2006 ident: BFnrm2451_CR66 publication-title: Oncogene doi: 10.1038/sj.onc.1209490 contributor: fullname: P Andrews – volume: 450 start-page: 721 year: 2007 ident: BFnrm2451_CR9 publication-title: Nature doi: 10.1038/nature05993 contributor: fullname: W Hu – volume: 79 start-page: 817 year: 1994 ident: BFnrm2451_CR98 publication-title: Cell doi: 10.1016/0092-8674(94)90071-X contributor: fullname: T Crook – volume: 130 start-page: 624 year: 2007 ident: BFnrm2451_CR89 publication-title: Cell doi: 10.1016/j.cell.2007.06.013 contributor: fullname: S Das – volume: 100 start-page: 8354 year: 2003 ident: BFnrm2451_CR31 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1432104100 contributor: fullname: K Mazan-Mamczarz – volume: 424 start-page: 516 year: 2003 ident: BFnrm2451_CR28 publication-title: Nature doi: 10.1038/nature01850 contributor: fullname: A Takaoka – volume: 18 start-page: 283 year: 2005 ident: BFnrm2451_CR11 publication-title: Mol. Cell doi: 10.1016/j.molcel.2005.03.027 contributor: fullname: RG Jones – volume: 112 start-page: 29 year: 2003 ident: BFnrm2451_CR67 publication-title: Cell doi: 10.1016/S0092-8674(02)01255-2 contributor: fullname: AY Nikolaev – volume: 102 start-page: 849 year: 2000 ident: BFnrm2451_CR81 publication-title: Cell doi: 10.1016/S0092-8674(00)00073-8 contributor: fullname: K Oda – volume: 21 start-page: 6123 year: 2002 ident: BFnrm2451_CR91 publication-title: Oncogene doi: 10.1038/sj.onc.1205842 contributor: fullname: V Budram-Mahadeo – volume: 278 start-page: 261 year: 1979 ident: BFnrm2451_CR1 publication-title: Nature doi: 10.1038/278261a0 contributor: fullname: DP Lane – volume: 26 start-page: 102 year: 2007 ident: BFnrm2451_CR38 publication-title: EMBO J. doi: 10.1038/sj.emboj.7601469 contributor: fullname: S Uldrijan – volume: 102 start-page: 10188 year: 2005 ident: BFnrm2451_CR48 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0503068102 contributor: fullname: KA Krummel – volume: 10 start-page: 2438 year: 1996 ident: BFnrm2451_CR76 publication-title: Genes Dev. doi: 10.1101/gad.10.19.2438 contributor: fullname: X Chen – volume: 173 start-page: 533 year: 2006 ident: BFnrm2451_CR84 publication-title: J. Cell Biol. doi: 10.1083/jcb.200512059 contributor: fullname: CD Knights – volume: 127 start-page: 775 year: 2006 ident: BFnrm2451_CR54 publication-title: Cell doi: 10.1016/j.cell.2006.09.031 contributor: fullname: L Le Cam – volume: 4 start-page: 1 year: 2002 ident: BFnrm2451_CR78 publication-title: Nature Cell Biol. doi: 10.1038/ncb715 contributor: fullname: TG Hofmann – volume: 29 start-page: 92 year: 2001 ident: BFnrm2451_CR37 publication-title: Nature Genet. doi: 10.1038/ng714 contributor: fullname: J Parant – volume: 14 start-page: 912 year: 2007 ident: BFnrm2451_CR95 publication-title: Nature Struct. Mol. Biol. doi: 10.1038/nsmb1306 contributor: fullname: F Mantovani – volume: 4 start-page: 233 year: 2003 ident: BFnrm2451_CR15 publication-title: Hematol. J. doi: 10.1038/sj.thj.6200260 contributor: fullname: YL Woods – volume: 62 start-page: 7316 year: 2002 ident: BFnrm2451_CR18 publication-title: Cancer Res. contributor: fullname: P Fei – volume: 24 start-page: 6728 year: 2004 ident: BFnrm2451_CR24 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.15.6728-6741.2004 contributor: fullname: S Erster – volume: 6 start-page: 313 year: 2003 ident: BFnrm2451_CR53 publication-title: Drug Resist. Update doi: 10.1016/j.drup.2003.10.004 contributor: fullname: A O'Brate – volume: 14 start-page: 6264 year: 1994 ident: BFnrm2451_CR23 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.14.9.6264 contributor: fullname: TG Graeber – volume: 26 start-page: 1477 year: 2007 ident: BFnrm2451_CR68 publication-title: Oncogene doi: 10.1038/sj.onc.1209924 contributor: fullname: A Laine – volume: 416 start-page: 560 year: 2002 ident: BFnrm2451_CR88 publication-title: Nature doi: 10.1038/416560a contributor: fullname: ER Flores – volume: 419 start-page: 853 year: 2002 ident: BFnrm2451_CR93 publication-title: Nature doi: 10.1038/nature01120 contributor: fullname: P Zacchi – ident: BFnrm2451_CR41 doi: 10.1038/nature02501 – volume: 8 start-page: 71 year: 2001 ident: BFnrm2451_CR102 publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00277-5 contributor: fullname: C Demonacos – volume: 25 start-page: 725 year: 2007 ident: BFnrm2451_CR80 publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.02.007 contributor: fullname: N Taira – volume: 27 start-page: 1425 year: 2007 ident: BFnrm2451_CR96 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00999-06 contributor: fullname: F Toledo – volume: 16 start-page: 4952 year: 1996 ident: BFnrm2451_CR97 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.16.9.4952 contributor: fullname: RL Ludwig – volume: 416 start-page: 648 year: 2002 ident: BFnrm2451_CR40 publication-title: Nature doi: 10.1038/nature737 contributor: fullname: M Li – volume: 142 start-page: 44 year: 1985 ident: BFnrm2451_CR60 publication-title: Virology doi: 10.1016/0042-6822(85)90421-0 contributor: fullname: A Zantema – volume: 6 start-page: 443 year: 2004 ident: BFnrm2451_CR72 publication-title: Nature Cell Biol. doi: 10.1038/ncb1123 contributor: fullname: JI Leu – volume: 16 start-page: 4117 year: 1997 ident: BFnrm2451_CR32 publication-title: EMBO J. doi: 10.1093/emboj/16.13.4117 contributor: fullname: L Fu – volume: 312 start-page: 1650 year: 2006 ident: BFnrm2451_CR12 publication-title: Science doi: 10.1126/science.1126863 contributor: fullname: S Matoba – volume: 12 start-page: 355 year: 2007 ident: BFnrm2451_CR39 publication-title: Cancer Cell doi: 10.1016/j.ccr.2007.09.007 contributor: fullname: K Itahana – volume: 19 start-page: 6185 year: 2000 ident: BFnrm2451_CR92 publication-title: EMBO J. doi: 10.1093/emboj/19.22.6185 contributor: fullname: V Fogal – volume: 13 start-page: 879 year: 2004 ident: BFnrm2451_CR42 publication-title: Mol. Cell doi: 10.1016/S1097-2765(04)00157-1 contributor: fullname: M Li – volume: 408 start-page: 307 year: 2000 ident: BFnrm2451_CR4 publication-title: Nature doi: 10.1038/35042675 contributor: fullname: B Vogelstein – volume: 302 start-page: 1036 year: 2003 ident: BFnrm2451_CR20 publication-title: Science doi: 10.1126/science.1090072 contributor: fullname: A Villunger – volume: 112 start-page: 779 year: 2003 ident: BFnrm2451_CR43 publication-title: Cell doi: 10.1016/S0092-8674(03)00193-4 contributor: fullname: RP Leng – volume: 8 start-page: 781 year: 2001 ident: BFnrm2451_CR86 publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00367-7 contributor: fullname: Y Samuels-Lev – volume: 22 start-page: 6068 year: 2003 ident: BFnrm2451_CR5 publication-title: EMBO J. doi: 10.1093/emboj/cdg579 contributor: fullname: CP Rubbi – volume: 17 start-page: 286 year: 2007 ident: BFnrm2451_CR13 publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2007.04.004 contributor: fullname: K Bensaad – volume: 444 start-page: 629 year: 2006 ident: BFnrm2451_CR49 publication-title: Nature doi: 10.1038/nature05287 contributor: fullname: J Huang – volume: 94 start-page: 14707 year: 1997 ident: BFnrm2451_CR61 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.26.14707 contributor: fullname: LW Elmore – volume: 11 start-page: 577 year: 2003 ident: BFnrm2451_CR71 publication-title: Mol. Cell doi: 10.1016/S1097-2765(03)00050-9 contributor: fullname: M Mihara – volume: 118 start-page: 83 year: 2004 ident: BFnrm2451_CR50 publication-title: Cell doi: 10.1016/j.cell.2004.06.016 contributor: fullname: DP Xirodimas – volume: 4 start-page: 11 year: 2002 ident: BFnrm2451_CR79 publication-title: Nature Cell Biol. doi: 10.1038/ncb714 contributor: fullname: G D'Orazi – volume: 419 start-page: 849 year: 2002 ident: BFnrm2451_CR94 publication-title: Nature doi: 10.1038/nature01116 contributor: fullname: H Zheng – volume: 34 start-page: 6640 year: 2006 ident: BFnrm2451_CR90 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl878 contributor: fullname: VS Budhram-Mahadeo – volume: 126 start-page: 121 year: 2006 ident: BFnrm2451_CR6 publication-title: Cell doi: 10.1016/j.cell.2006.05.034 contributor: fullname: D Crighton – volume: 4 start-page: 321 year: 2003 ident: BFnrm2451_CR21 publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00244-7 contributor: fullname: JR Jeffers – volume: 28 start-page: 387 year: 1982 ident: BFnrm2451_CR59 publication-title: Cell doi: 10.1016/0092-8674(82)90356-7 contributor: fullname: P Sarnow – volume: 21 start-page: 307 year: 2006 ident: BFnrm2451_CR33 publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.01.020 contributor: fullname: CL Brooks – volume: 25 start-page: 5389 year: 2005 ident: BFnrm2451_CR47 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.13.5389-5395.2005 contributor: fullname: L Feng – volume: 282 start-page: 3273 year: 2007 ident: BFnrm2451_CR45 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M610793200 contributor: fullname: W Yang – volume: 4 start-page: 365 year: 1999 ident: BFnrm2451_CR100 publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80338-X contributor: fullname: N Shikama – volume: 14 start-page: 1561 year: 2007 ident: BFnrm2451_CR46 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4402196 contributor: fullname: A Olsson – volume: 12 start-page: 369 year: 2005 ident: BFnrm2451_CR57 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401562 contributor: fullname: V Fogal – volume: 313 start-page: 968 year: 2006 ident: BFnrm2451_CR14 publication-title: Science doi: 10.1126/science.1126391 contributor: fullname: JG Teodoro – volume: 23 start-page: 7083 year: 2003 ident: BFnrm2451_CR30 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.20.7083-7095.2003 contributor: fullname: S Galban – volume: 13 start-page: 2575 year: 1996 ident: BFnrm2451_CR16 publication-title: Oncogene contributor: fullname: DE MacCallum – volume: 9 start-page: 428 year: 2007 ident: BFnrm2451_CR65 publication-title: Nature Cell Biol. doi: 10.1038/ncb1562 contributor: fullname: S Carter – volume: 303 start-page: 1010 year: 2004 ident: BFnrm2451_CR73 publication-title: Science doi: 10.1126/science.1092734 contributor: fullname: JE Chipuk – volume: 29 start-page: 217 year: 2008 ident: BFnrm2451_CR103 publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.11.036 contributor: fullname: M Kitagawa – volume: 65 start-page: 9971 year: 2005 ident: BFnrm2451_CR74 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-1084 contributor: fullname: F Talos – volume: 302 start-page: 1972 year: 2003 ident: BFnrm2451_CR63 publication-title: Science doi: 10.1126/science.1091362 contributor: fullname: M Li – volume: 26 start-page: 923 year: 2007 ident: BFnrm2451_CR69 publication-title: EMBO J. doi: 10.1038/sj.emboj.7601560 contributor: fullname: ND Marchenko – volume: 443 start-page: 214 year: 2006 ident: BFnrm2451_CR107 publication-title: Nature doi: 10.1038/nature05077 contributor: fullname: MA Christophorou – volume: 19 start-page: 649 year: 2000 ident: BFnrm2451_CR19 publication-title: Oncogene doi: 10.1038/sj.onc.1203366 contributor: fullname: V Bouvard – volume: 24 start-page: 841 year: 2006 ident: BFnrm2451_CR82 publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.11.026 contributor: fullname: SM Sykes – volume: 117 start-page: 326 year: 2007 ident: BFnrm2451_CR7 publication-title: J. Clin. Invest. doi: 10.1172/JCI28833 contributor: fullname: RK Amaravadi – volume: 6 start-page: 909 year: 2006 ident: BFnrm2451_CR27 publication-title: Nature Rev. Cancer doi: 10.1038/nrc2012 contributor: fullname: F Toledo – volume: 19 start-page: 3791 year: 2000 ident: BFnrm2451_CR17 publication-title: Oncogene doi: 10.1038/sj.onc.1203717 contributor: fullname: EA Komarova – volume: 20 start-page: 8458 year: 2000 ident: BFnrm2451_CR51 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.22.8458-8467.2000 contributor: fullname: MS Rodriguez – volume: 130 start-page: 638 year: 2007 ident: BFnrm2451_CR104 publication-title: Cell doi: 10.1016/j.cell.2007.08.001 contributor: fullname: T Tanaka – volume: 21 start-page: 3095 year: 2007 ident: BFnrm2451_CR75 publication-title: Genes Dev. doi: 10.1101/gad.1567107 contributor: fullname: JI Leu – volume: 14 start-page: 981 year: 2000 ident: BFnrm2451_CR25 publication-title: Genes Dev. doi: 10.1101/gad.827700 contributor: fullname: R Zhao – volume: 22 start-page: 78 year: 2002 ident: BFnrm2451_CR58 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.1.78-93.2002 contributor: fullname: JK Hsieh – volume: 98 start-page: 141 year: 2006 ident: BFnrm2451_CR8 publication-title: Biol. Cell doi: 10.1042/BC20050058 contributor: fullname: L Roger – volume: 429 start-page: 86 year: 2004 ident: BFnrm2451_CR44 publication-title: Nature doi: 10.1038/nature02514 contributor: fullname: D Dornan – volume: 123 start-page: 49 year: 2005 ident: BFnrm2451_CR29 publication-title: Cell doi: 10.1016/j.cell.2005.07.034 contributor: fullname: M Takagi – volume: 82 start-page: 761 year: 2006 ident: BFnrm2451_CR26 publication-title: Int. J. Radiat. Biol. doi: 10.1080/09553000600949624 contributor: fullname: S Alvarez – volume: 13 start-page: 927 year: 2006 ident: BFnrm2451_CR34 publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401912 contributor: fullname: JC Marine – volume: 76 start-page: 2420 year: 1979 ident: BFnrm2451_CR3 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.76.5.2420 contributor: fullname: AB DeLeo – volume: 10 start-page: 676 year: 2008 ident: BFnrm2451_CR70 publication-title: Nature Cell Biol. doi: 10.1038/ncb1730 contributor: fullname: E Tasdemir – volume: 75 start-page: 765 year: 1993 ident: BFnrm2451_CR22 publication-title: Cell doi: 10.1016/0092-8674(93)90496-D contributor: fullname: X Lu – volume: 15 start-page: 1895 year: 1997 ident: BFnrm2451_CR62 publication-title: Oncogene doi: 10.1038/sj.onc.1201369 contributor: fullname: S Takada – volume: 126 start-page: 107 year: 2006 ident: BFnrm2451_CR10 publication-title: Cell doi: 10.1016/j.cell.2006.05.036 contributor: fullname: K Bensaad – volume: 378 start-page: 203 year: 1995 ident: BFnrm2451_CR36 publication-title: Nature doi: 10.1038/378203a0 contributor: fullname: R Montes de Oca Luna – volume: 18 start-page: 1660 year: 1999 ident: BFnrm2451_CR56 publication-title: EMBO J. doi: 10.1093/emboj/18.6.1660 contributor: fullname: JM Stommel – volume: 449 start-page: 105 year: 2007 ident: BFnrm2451_CR52 publication-title: Nature doi: 10.1038/nature06092 contributor: fullname: J Huang – volume: 17 start-page: 43 year: 1979 ident: BFnrm2451_CR2 publication-title: Cell doi: 10.1016/0092-8674(79)90293-9 contributor: fullname: DI Linzer – volume: 24 start-page: 827 year: 2006 ident: BFnrm2451_CR83 publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.11.021 contributor: fullname: Y Tang – volume: 9 start-page: 1175 year: 2007 ident: BFnrm2451_CR55 publication-title: Nature Cell Biol. doi: 10.1038/ncb1638 contributor: fullname: M Kanai |
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The tumour suppressor p53 is a master sensor of stress and integrates incoming signals to prevent malignant progression by inducing cellular... The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This... |
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SubjectTerms | Animals Apoptosis Bar codes Biochemistry Biomedical and Life Sciences Cancer Cancer Research Cell Biology Cell growth Cellular signal transduction Developmental Biology Genes Genetic aspects Health aspects Heterogeneity Humans Life Sciences Medical research Mutation Organ Specificity Physiology Protein Transport Proteins review-article Senescence Stem Cells Stress, Physiological - metabolism Telomerase Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism |
Title | A complex barcode underlies the heterogeneous response of p53 to stress |
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