Anti-Influenza Virus Activity and Chemical Components from the Parasitic Plant Cuscuta japonica Choisy on Dimocarpus longans Lour

Dodder (Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese dodder) parasitizes Dimocarpus longans Lour., Ficus septica Burm. F., Ficus microcarpa L.f., Mikania micrantha H.B.K. and Melia azedarach Linn, r...

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Published inMolecules (Basel, Switzerland) Vol. 25; no. 19; p. 4427
Main Authors Cheng, Ju-Chien, Liaw, Chia-Ching, Lin, Ming-Kuem, Chen, Chao-Jung, Chao, Chien-Liang, Chao, Chih-Hua, Kuo, Yueh-Hsiung, Chiu, Yen-Po, Peng, Yu-Shin, Huang, Hui-Chi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.09.2020
MDPI
Subjects
Animals
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral drugs
Carbon
Cuscuta - chemistry
Cuscuta japonica Choisy
cuscutasides
Cytotoxicity
Dimocarpus longans Lour
Dogs
Fatty acids
Influenza
influenza A virus (IAV)
Influenza A Virus, H1N1 Subtype - growth & development
Madin Darby Canine Kidney Cells
Orthomyxoviridae Infections - drug therapy
Orthomyxoviridae Infections - metabolism
Orthomyxoviridae Infections - pathology
parasitic plant
Phytochemicals
Plant Extracts - chemistry
Plant Extracts - pharmacology
Sapindaceae
Seeds
Spectrum analysis
cuscutasides
parasitic plant
Cuscuta japonica Choisy
Dimocarpus longans Lour
influenza A virus (IAV)
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Abstract Dodder (Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese dodder) parasitizes Dimocarpus longans Lour., Ficus septica Burm. F., Ficus microcarpa L.f., Mikania micrantha H.B.K. and Melia azedarach Linn, respectively. Five Japanese dodders growing on different plants exhibit slightly different metabolites and amounts which present different pharmacological effects. Among these plants, a significant antiviral activity against influenza A virus (IAV) was found in Japanese dodder parasitizing on D. longans Lour. (CL). To further explore methanol extract components in Japanese dodder (CL), four undescribed aromatic glycosides, cuscutasides A–D (compounds 1–4) were isolated, together with twenty-six known compounds 5–30. The chemical structures of 1–4 were elucidated using a combination of spectroscopic techniques. The eighteen isolated compounds were evaluated for antiviral activity against IAV activity. Among them, 1-monopalmitin (29) displayed potent activity against influenza A virus (A/WSN/1933(H1N1)) with EC50 2.28 ± 0.04 μM and without noteworthy cytotoxicity in MDCK cells. The interrupt step of 29 on the IAV life cycle was determined. These data provide invaluable information for new applications for this otherwise harmful weed.
AbstractList Dodder ( spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Choisy (Japanese dodder) parasitizes Lour., Burm. F., L.f., H.B.K. and Linn, respectively. Five Japanese dodders growing on different plants exhibit slightly different metabolites and amounts which present different pharmacological effects. Among these plants, a significant antiviral activity against influenza A virus (IAV) was found in Japanese dodder parasitizing on Lour. (CL). To further explore methanol extract components in Japanese dodder (CL), four undescribed aromatic glycosides, cuscutasides A-D (compounds - ) were isolated, together with twenty-six known compounds - . The chemical structures of - were elucidated using a combination of spectroscopic techniques. The eighteen isolated compounds were evaluated for antiviral activity against IAV activity. Among them, 1-monopalmitin ( ) displayed potent activity against influenza A virus (A/WSN/1933(H1N1)) with EC 2.28 ± 0.04 μM and without noteworthy cytotoxicity in MDCK cells. The interrupt step of on the IAV life cycle was determined. These data provide invaluable information for new applications for this otherwise harmful weed.
Dodder (Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese dodder) parasitizes Dimocarpus longans Lour., Ficus septica Burm. F., Ficus microcarpa L.f., Mikania micrantha H.B.K. and Melia azedarach Linn, respectively. Five Japanese dodders growing on different plants exhibit slightly different metabolites and amounts which present different pharmacological effects. Among these plants, a significant antiviral activity against influenza A virus (IAV) was found in Japanese dodder parasitizing on D. longans Lour. (CL). To further explore methanol extract components in Japanese dodder (CL), four undescribed aromatic glycosides, cuscutasides A-D (compounds 1-4) were isolated, together with twenty-six known compounds 5-30. The chemical structures of 1-4 were elucidated using a combination of spectroscopic techniques. The eighteen isolated compounds were evaluated for antiviral activity against IAV activity. Among them, 1-monopalmitin (29) displayed potent activity against influenza A virus (A/WSN/1933(H1N1)) with EC50 2.28 ± 0.04 μM and without noteworthy cytotoxicity in MDCK cells. The interrupt step of 29 on the IAV life cycle was determined. These data provide invaluable information for new applications for this otherwise harmful weed.Dodder (Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese dodder) parasitizes Dimocarpus longans Lour., Ficus septica Burm. F., Ficus microcarpa L.f., Mikania micrantha H.B.K. and Melia azedarach Linn, respectively. Five Japanese dodders growing on different plants exhibit slightly different metabolites and amounts which present different pharmacological effects. Among these plants, a significant antiviral activity against influenza A virus (IAV) was found in Japanese dodder parasitizing on D. longans Lour. (CL). To further explore methanol extract components in Japanese dodder (CL), four undescribed aromatic glycosides, cuscutasides A-D (compounds 1-4) were isolated, together with twenty-six known compounds 5-30. The chemical structures of 1-4 were elucidated using a combination of spectroscopic techniques. The eighteen isolated compounds were evaluated for antiviral activity against IAV activity. Among them, 1-monopalmitin (29) displayed potent activity against influenza A virus (A/WSN/1933(H1N1)) with EC50 2.28 ± 0.04 μM and without noteworthy cytotoxicity in MDCK cells. The interrupt step of 29 on the IAV life cycle was determined. These data provide invaluable information for new applications for this otherwise harmful weed.
Dodder (Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese dodder) parasitizes Dimocarpus longans Lour., Ficus septica Burm. F., Ficus microcarpa L.f., Mikania micrantha H.B.K. and Melia azedarach Linn, respectively. Five Japanese dodders growing on different plants exhibit slightly different metabolites and amounts which present different pharmacological effects. Among these plants, a significant antiviral activity against influenza A virus (IAV) was found in Japanese dodder parasitizing on D. longans Lour. (CL). To further explore methanol extract components in Japanese dodder (CL), four undescribed aromatic glycosides, cuscutasides A–D (compounds 1–4) were isolated, together with twenty-six known compounds 5–30. The chemical structures of 1–4 were elucidated using a combination of spectroscopic techniques. The eighteen isolated compounds were evaluated for antiviral activity against IAV activity. Among them, 1-monopalmitin (29) displayed potent activity against influenza A virus (A/WSN/1933(H1N1)) with EC50 2.28 ± 0.04 μM and without noteworthy cytotoxicity in MDCK cells. The interrupt step of 29 on the IAV life cycle was determined. These data provide invaluable information for new applications for this otherwise harmful weed.
Dodder ( Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese dodder) parasitizes Dimocarpus longans Lour., Ficus septica Burm. F., Ficus microcarpa L.f., Mikania micrantha H.B.K. and Melia azedarach Linn, respectively. Five Japanese dodders growing on different plants exhibit slightly different metabolites and amounts which present different pharmacological effects. Among these plants, a significant antiviral activity against influenza A virus (IAV) was found in Japanese dodder parasitizing on D. longans Lour. (CL). To further explore methanol extract components in Japanese dodder (CL), four undescribed aromatic glycosides, cuscutasides A–D (compounds 1 – 4 ) were isolated, together with twenty-six known compounds 5 – 30 . The chemical structures of 1 – 4 were elucidated using a combination of spectroscopic techniques. The eighteen isolated compounds were evaluated for antiviral activity against IAV activity. Among them, 1-monopalmitin ( 29 ) displayed potent activity against influenza A virus (A/WSN/1933(H1N1)) with EC 50 2.28 ± 0.04 μM and without noteworthy cytotoxicity in MDCK cells. The interrupt step of 29 on the IAV life cycle was determined. These data provide invaluable information for new applications for this otherwise harmful weed.
Author Cheng, Ju-Chien
Liaw, Chia-Ching
Lin, Ming-Kuem
Huang, Hui-Chi
Kuo, Yueh-Hsiung
Chiu, Yen-Po
Chao, Chien-Liang
Peng, Yu-Shin
Chen, Chao-Jung
Chao, Chih-Hua
AuthorAffiliation 2 Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan; liawcc@nricm.edu.tw
6 Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
8 School of Pharmacy, China Medical University, Taichung 404, Taiwan; chchao@mail.cmu.edu.tw
11 Master Program for Food and Drug Safety, China Medical University, Taichung 404, Taiwan
1 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan; jccheng@mail.cmu.edu.tw (J.-C.C.); albert50137@gmail.com (Y.-P.C.); sean56789912@gmail.com (Y.-S.P.)
10 Department of Biotechnology, Asia University, Taichung 413, Taiwan
3 Department of Biochemical Science and Technology, National Chiayi University, Chiayi 60004, Taiwan
5 Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan; cjchen@mail.cmu.edu.tw
7 Sinphar Pharmaceutical Co., Ltd., Sinphar Group, Yilan 269, Taiwan;
AuthorAffiliation_xml – name: 6 Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
– name: 10 Department of Biotechnology, Asia University, Taichung 413, Taiwan
– name: 1 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan; jccheng@mail.cmu.edu.tw (J.-C.C.); albert50137@gmail.com (Y.-P.C.); sean56789912@gmail.com (Y.-S.P.)
– name: 3 Department of Biochemical Science and Technology, National Chiayi University, Chiayi 60004, Taiwan
– name: 4 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan; linmk@mail.cmu.edu.tw (M.-K.L.); kuoyh@mail.cmu.edu.tw (Y.-H.K.)
– name: 5 Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan; cjchen@mail.cmu.edu.tw
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– name: 2 Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan; liawcc@nricm.edu.tw
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– name: 11 Master Program for Food and Drug Safety, China Medical University, Taichung 404, Taiwan
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Keywords cuscutasides
parasitic plant
Cuscuta japonica Choisy
Dimocarpus longans Lour
influenza A virus (IAV)
Language English
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Snippet Dodder (Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese...
Dodder ( spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Choisy (Japanese dodder) parasitizes Lour.,...
Dodder ( Cuscuta spp.) is a parasitic weed damaging many plants and agricultural production. The native obligate parasite Cuscuta japonica Choisy (Japanese...
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StartPage 4427
SubjectTerms Animals
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral drugs
Carbon
Cuscuta - chemistry
Cuscuta japonica Choisy
cuscutasides
Cytotoxicity
Dimocarpus longans Lour
Dogs
Fatty acids
Influenza
influenza A virus (IAV)
Influenza A Virus, H1N1 Subtype - growth & development
Madin Darby Canine Kidney Cells
Orthomyxoviridae Infections - drug therapy
Orthomyxoviridae Infections - metabolism
Orthomyxoviridae Infections - pathology
parasitic plant
Phytochemicals
Plant Extracts - chemistry
Plant Extracts - pharmacology
Sapindaceae
Seeds
Spectrum analysis
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Title Anti-Influenza Virus Activity and Chemical Components from the Parasitic Plant Cuscuta japonica Choisy on Dimocarpus longans Lour
URI https://www.ncbi.nlm.nih.gov/pubmed/32993192
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Volume 25
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