Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer

• Published in: Journal of gastric cancer Vol. 20; no. 4; pp. 408 - 420
• Main Authors: Kim, Seo Ree, Shin, Kabsoo, Park, Jae Myung, Lee, Han Hong, Song, Kyo Yong, Lee, Sung Hak, Kim, Bohyun, Kim, Sang-Yeob, Seo, Junyoung, Kim, Jeong-Oh, Roh, Sang-Young, Kim, In-Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Gastric Cancer Association 01.12.2020; 대한위암학회
• Subjects: Original; 일반외과학; Cadherins; Chemotherapy; Gastric cancer; Claudin

Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-act...