Investigation of CACNA1I Cav3.3 Dysfunction in Hemiplegic Migraine

• Published in: Frontiers in molecular neuroscience Vol. 15; p. 892820
• Main Authors: Maksemous, Neven, Blayney, Claire D, Sutherland, Heidi G, Smith, Robert A, Lea, Rod A, Tran, Kim Ngan, Ibrahim, Omar, McArthur, Jeffrey R, Haupt, Larisa M, Cader, M Zameel, Finol-Urdaneta, Rocio K, Adams, David J, Griffiths, Lyn R
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 19.07.2022; Frontiers Media S.A
• Subjects: Acidosis; Alkalosis; Ataxia; CACNA1I; Calcium channels; Calcium channels (T-type); Calcium channels (voltage-gated); Cav3.3; Electrophysiology; familial hemiplegic migraine; Gene expression; Genomics; Headache; hemiplegic migraine; ion channel; Kinetics; Migraine; migraine genetics; Molecular Neuroscience; Mutation; Proteins; Sodium channels (voltage-gated); Statistical analysis; Australia; United States > US; CACNA1I; Cav3.3; familial hemiplegic migraine; voltage gated calcium channels; ion channel; hemiplegic migraine; T-type calcium channels; migraine genetics

Familial hemiplegic migraine (FHM) is a severe neurogenetic disorder for which three causal genes, , , and , have been implicated. However, more than 80% of referred diagnostic cases of hemiplegic migraine (HM) are negative for exonic mutations in these known FHM genes, suggesting the involvement of...